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Characteristics of the Deconvolved Transient AEP from 80 Hz Steady-State Responses to Amplitude Modulation Stimulation

A Correction to this article was published on 07 October 2021

This article has been updated

Abstract

This study aimed to validate the existence and investigate the characteristics of the transient responses from conventional auditory steady-state responses (ASSRs) using deconvolution methods capable of dealing with amplitude modulated (AM) stimulation. Conventional ASSRs to seven stimulus rates were recorded from 17 participants. A deconvolution method was selected and modified to accommodate the AM stimulation. The calculated responses were examined in terms of temporal features with respect to different combinations of stimulus rates. Stable transient responses consisting of early stage brainstem responses and middle latency responses were reconstructed consistently for all rate combinations, which indicates that the superposition hypothesis is applicable to the generation of approximately 80 Hz ASSRs evoked by AM tones (AM-ASSRs). The new transient responses are characterized by three pairs of peak-troughs named as n0p0, n1p1, and n2p2 within 40 ms. Compared with conventional ABR-MLRs, the n0p0 indicates the first neural activity where p0 might represent the main ABR components; the n1 is the counterpart of N10; the p2 is corresponding to the robust Pa at about 30 ms; the p1 and n2 are absent of real counterparts. The peak–peak amplitudes show a slight decrease with increasing stimulation rate from 75 to 95 Hz whereas the peak latencies change differently, which is consistent with the known rate-effect on AEPs. This is direct evidence for a transient response derived from AM-ASSRs for the first time. The characteristic components offer insight into the constitution of AM-ASSRs and may be promising in clinical applications and fundamental studies.

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Data Availability and Material

Data and material are available in figshare, https://doi.org/10.6084/m9.figshare.14775975.

Code Availability

Codes of software are available in figshare, https://doi.org/10.6084/m9.figshare.14775975.

Change history

  • 07 October 2021

    This article has been corrected to include the statement “Tao Wang and Yuner Chen are both first authors with equal contributions” in the PDF.

  • 07 October 2021

    A Correction to this paper has been published: https://doi.org/10.1007/s10162-021-00818-y

Abbreviations

ABR:

Auditory brainstem response

AEP:

Auditory evoked potential

AM:

Amplitude modulation

AM-ASSR:

ASSR evoked by AM pure tone

AM-tAEP:

Reconstructed tAEP from AM-ASSR and considered as the response elicited by one sound element in AM tone

ASSR:

Auditory steady-state response

CLAD:

Continuous loop averaging deconvolution

click-tAEP:

Reconstructed tAEP from ASSR evoked by clicks at high rates and considered as the response evoked by one click stimulus in a click sequence at high repetition rates

EEG:

Electroencephalograph

ISI:

Interstimulus interval

MLR:

Middle latency response

MLS:

Maximum length sequence

MSAD:

Multirate steady-state averaging deconvolution

SNR:

Signal-to-noise ratio

SVD:

Singular value decomposition, a mathematical tool

tAEP:

Transient AEP

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Acknowledgements

The authors thank statistician Jun Qian for her technical support on statistical analysis.

Funding

This work was supported by the Science and Technology Program of Guangzhou, China under Grant 201,804,010,282.

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Authors

Contributions

All authors contributed to the study, conception and design. Material preparation, data collection and analysis were performed by Tao Wang, Yuner Chen, and Xiaodan Tan. The first draft of the manuscript was written by Xiaodan Tan and Qiuyang Fu. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Xiaodan Tan.

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Ethics Approval

The experiment was approved by the Human Research Ethics Committee of Southern Medical University (No. 2015-KYLL-004).

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Every participant signed the corresponding informed consent forms prior to the experiment.

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All authors read and approved the final manuscript and publication.

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The authors declare no competing interests.

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Wang, T., Chen, Y., Fu, Q. et al. Characteristics of the Deconvolved Transient AEP from 80 Hz Steady-State Responses to Amplitude Modulation Stimulation. JARO (2021). https://doi.org/10.1007/s10162-021-00806-2

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Keywords

  • Amplitude modulation tone
  • Auditory steady-state response
  • Linear superposition hypothesis
  • Multirate steady-state averaging deconvolution method
  • Rate combination