This study aimed to validate the existence and investigate the characteristics of the transient responses from conventional auditory steady-state responses (ASSRs) using deconvolution methods capable of dealing with amplitude modulated (AM) stimulation. Conventional ASSRs to seven stimulus rates were recorded from 17 participants. A deconvolution method was selected and modified to accommodate the AM stimulation. The calculated responses were examined in terms of temporal features with respect to different combinations of stimulus rates. Stable transient responses consisting of early stage brainstem responses and middle latency responses were reconstructed consistently for all rate combinations, which indicates that the superposition hypothesis is applicable to the generation of approximately 80 Hz ASSRs evoked by AM tones (AM-ASSRs). The new transient responses are characterized by three pairs of peak-troughs named as n0p0, n1p1, and n2p2 within 40 ms. Compared with conventional ABR-MLRs, the n0p0 indicates the first neural activity where p0 might represent the main ABR components; the n1 is the counterpart of N10; the p2 is corresponding to the robust Pa at about 30 ms; the p1 and n2 are absent of real counterparts. The peak–peak amplitudes show a slight decrease with increasing stimulation rate from 75 to 95 Hz whereas the peak latencies change differently, which is consistent with the known rate-effect on AEPs. This is direct evidence for a transient response derived from AM-ASSRs for the first time. The characteristic components offer insight into the constitution of AM-ASSRs and may be promising in clinical applications and fundamental studies.
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Data Availability and Material
Data and material are available in figshare, https://doi.org/10.6084/m9.figshare.14775975.
Codes of software are available in figshare, https://doi.org/10.6084/m9.figshare.14775975.
Auditory brainstem response
Auditory evoked potential
ASSR evoked by AM pure tone
Reconstructed tAEP from AM-ASSR and considered as the response elicited by one sound element in AM tone
Auditory steady-state response
Continuous loop averaging deconvolution
Reconstructed tAEP from ASSR evoked by clicks at high rates and considered as the response evoked by one click stimulus in a click sequence at high repetition rates
Middle latency response
Maximum length sequence
Multirate steady-state averaging deconvolution
Singular value decomposition, a mathematical tool
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The authors thank statistician Jun Qian for her technical support on statistical analysis.
This work was supported by the Science and Technology Program of Guangzhou, China under Grant 201,804,010,282.
The experiment was approved by the Human Research Ethics Committee of Southern Medical University (No. 2015-KYLL-004).
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Wang, T., Chen, Y., Fu, Q. et al. Characteristics of the Deconvolved Transient AEP from 80 Hz Steady-State Responses to Amplitude Modulation Stimulation. JARO (2021). https://doi.org/10.1007/s10162-021-00806-2
- Amplitude modulation tone
- Auditory steady-state response
- Linear superposition hypothesis
- Multirate steady-state averaging deconvolution method
- Rate combination