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Eye Movements Are Correctly Timed During Walking Despite Bilateral Vestibular Hypofunction

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Abstract

Individuals with bilateral vestibular hypofunction (BVH) often report symptoms of oscillopsia (the perception that the world is bouncing or unstable) during walking. Efference copy/proprioception contributes to locomotion gaze stability in animals, sometimes inhibiting the vestibulo-ocular reflex (VOR). Gaze stability requires both adequate eye velocity and appropriate timing of eye movements. It is unknown whether eye velocity (VOR gain), timing (phase), or both are impaired for individuals with BVH during walking. Identifying the specific mechanism of impaired gaze stability can better inform rehabilitation options. Gaze stability was measured for eight individuals with severe BVH and eight healthy age- and gender-matched controls while performing a gaze fixation task during treadmill walking. Frequency response functions (FRF) were calculated from pitch eye and head velocity. A one-way ANOVA was conducted to determine group differences for each frequency bin of the FRF. Pearson correlation coefficients were calculated to determine the relationship between the real and imaginary parts of the FRF and the Oscillopsia Visual Analog Scale (oVAS) scores. Individuals with BVH demonstrated significantly lower gains than healthy controls above 0.5 Hz, but their phase was ideally compensatory for frequencies below 3 Hz. Higher oVAS scores were correlated with lower gain. Individuals with BVH demonstrated ideal timing for vertical eye movements while walking despite slower than ideal eye velocity when compared to healthy controls. Rehabilitation interventions focusing on enhancing VOR gain during walking should be developed to take advantage of the intact timing reported here. Specifically, training VOR gain while walking may reduce oscillopsia severity and improve quality of life.

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Acknowledgements

Thanks to Amy Bastian, PT, PhD, for sharing lab and equipment space for this study.

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Authors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery and the David M. Rubinstein Hearing Center, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Eric R. Anson & John P. Carey

  2. Johns Hopkins Outpatient Center, 601 N. Caroline Street, Ste 6030D, Baltimore, MD, 21287, USA

    Eric R. Anson

  3. Kinesiology Department, University of Maryland, College Park, MD, USA

    Tim Kiemel

  4. Department of Kinesiology, Temple University, Philadelphia, 19122, PA, United States

    John J. Jeka

  5. Department of Bioengineering, Temple University, Philadelphia, PA, USA

    John J. Jeka

  6. Shriners Hospital for Children, Philadelphia, PA, USA

    John J. Jeka

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  1. Eric R. Anson
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  2. Tim Kiemel
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  4. John J. Jeka
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Correspondence to Eric R. Anson.

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The authors declare that they have no conflicts of interest.

Source of Funding

This work was supported in part by PODS Scholarships from the Foundation for Physical Therapy, Inc. (E Anson, PI); a Wylie Dissertation Fellowship from the University of Maryland Graduate School (E Anson, PI); the University of Maryland’s Department of Kinesiology Graduate Student Research Initiative Fund (E Anson, PI); and National Institutes of Health grant R21 AG041714-01A1 (J Jeka, PI). For the remaining authors, none were declared.

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A version of this manuscript has been published in electronic form as a dissertation chapter in fulfillment of doctoral degree requirements under copyright by E Anson.

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Anson, E.R., Kiemel, T., Carey, J.P. et al. Eye Movements Are Correctly Timed During Walking Despite Bilateral Vestibular Hypofunction. JARO 18, 591–600 (2017). https://doi.org/10.1007/s10162-017-0626-8

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  • DOI: https://doi.org/10.1007/s10162-017-0626-8

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