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Extracellular vesicles carrying miRNAs in kidney diseases: a systemic review

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Abstract

MiRNAs play essential roles in processes of physiological status and disease conditions including in renal diseases, while extracellular vesicles (EVs) serve as important mediators for cell–cell communication. In body fluid or extracellular spaces, miRNAs are packaged into EVs and transferred to targeted cells to perform their bioeffects under particular conditions. In the present review, we aim to summarize and update the known and verified EV-carrying miRNAs (EV-miRNAs) and their general roles in kidney diseases. In addition to performing a systemic analysis, we try to provide some clues and perspectives for the future study of EV-miRNAs in renal diseases.

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Abbreviations

AKI:

Acute kidney injury

IgAN:

IgA Nephropathy

FSGS/MCD:

Focal segmental glomerulosclerosis/minimal change disease (nephropathy)

CKD:

Chronic kidney disease

DN:

Diabetic nephropathy

DKD:

Diabetic kidney disease

LN:

Lupus nephritis

DM:

Diabetes mellitus

MA:

Albuminuri

HG:

High glucos

EMP:

Endothelial microparticle

MIC/MAC:

Microalbuminuria/macroabuminuria

NGT:

Normal glucose

EH:

Essential hypertension

RVH:

Renovascular hypertension

ccRCC:

Clear cell renal cell carcinoma

RAPC:

Renal artery-derived vascular progenitor cells

hWJMSC:

Human Wharton jelly mesenchymal stromal cells

ECFC:

Human endothelial colony forming cell

BM:

Bone marrow

MSC:

Mesenchymal stromal cells

HLSC:

Human liver stem cell

MC:

Mesangial cells

UUO:

Unilateral ureteral occlusion

IRI:

Ischemia–reperfusion injury

EPO:

Erythropoietin

MV:

Microvesicles

HCAEC:

Human coronary artery endothelial cells

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Acknowledgements

The study was supported by grants from the National Natural Sciences Foundation of China (81870498, 81900633).

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Authors and Affiliations

  1. Department of Nephrology, Central South University, Hunan, The Third Xiangya HospitalNo.138 Tongzipo Road, Changsha, 410013, China

    Wei Zhang, Bin Yi, Shi-Kun Yang, Aimei Li, Jianwen Wang & Hao Zhang

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  1. Wei Zhang
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  2. Bin Yi
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  3. Shi-Kun Yang
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  4. Aimei Li
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  5. Jianwen Wang
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Correspondence to Hao Zhang.

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Zhang, W., Yi, B., Yang, SK. et al. Extracellular vesicles carrying miRNAs in kidney diseases: a systemic review. Clin Exp Nephrol 24, 1103–1121 (2020). https://doi.org/10.1007/s10157-020-01947-z

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