Deterioration of presarcopenia and its risk factors following kidney transplantation



Sarcopenia is prevalent in patients with chronic kidney disease and is associated with increased mortality; however, limited data are available on whether kidney transplantation can improve muscle wasting. Therefore, the present study aimed to assess changes in body composition before and after kidney transplantation.


Between April 2015 and January 2018, 80 de novo consecutive adult patients with end-stage kidney disease who underwent kidney transplantation were prospectively enrolled. Muscle and fat masses were measured via bioelectrical impedance analysis using InBody 770 at  − 2 and 7 days and 3, 6, and 12 months after transplantation. Presarcopenia is characterized by low muscle mass according to the skeletal muscle mass index. Changes in body composition and prevalence of presarcopenia were compared before and after transplantation. Risk factors for presarcopenia were identified using logistic regression analysis.


Muscle mass significantly decreased at 3 months after transplantation. Consequently, the prevalence of presarcopenia was significantly higher after transplantation (3 months: 47.5%, 6 months: 42.5%, and 12 months: 38.8%) than that before transplantation (25.0%). Similarly, the body fat percentage was significantly higher at 3 months after transplantation than that before transplantation. Presarcopenia before transplantation was an independent risk factor for presarcopenia at 12 months after transplantation (odds ratio: 51.8, 95% CI 5.77–464, p < 0.001).


Muscle wasting deteriorated and body fat percentage increased from 3 months after kidney transplantation. Presarcopenia before transplantation led to presarcopenia after transplantation, which may deteriorate with an increase in body fat percentage.

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The authors would like to thank Enago ( for the English language review.

Author information




KN designed the research, analyzed the data, and wrote the manuscript. NK measured body composition and collected data. All authors contributed to this research study and approved the final manuscript.

Corresponding author

Correspondence to Koji Nanmoku.

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The authors have declared that no conflict of interest exists.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee at which the studies were conducted (IRB approval no. 15–067) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Nanmoku, K., Kawabata, N., Kinoshita, Y. et al. Deterioration of presarcopenia and its risk factors following kidney transplantation. Clin Exp Nephrol 24, 379–383 (2020).

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  • Sarcopenia
  • Body composition
  • Muscle wasting
  • Body fat percentage
  • Chronic kidney disease