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Clinical impact of abdominal fat distribution measured by 3-D computed tomography volumetry on post-transplant renal function in recipients after living kidney transplantation: a retrospective study

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Abstract

Background

Excessive visceral fat may decrease renal function because of metabolic derangements. The aim of this study was to evaluate the impact of abdominal fat distribution on renal function of recipients after kidney transplantation using the visceral adipose tissue (VAT)/subcutaneous adipose tissue (SAT) ratio.

Methods

Seventy-nine patients underwent living kidney transplantation from 2009 to 2017. Patients without a correct measurement of VAT and SAT, follow-up of < 6 months, or with kidney transplant rejection or a virus infection were excluded. VAT and SAT were calculated automatically by 3-D volume analyzer software in recipients prior to living kidney transplantation. Our primary aim was to identify abdominal fat distribution measured by CT associated with renal dysfunction (estimate glomerular filtration rate; eGFR < 45) at 6 month post renal transplantation in recipient.

Results

Fifty-eight living kidney recipients were included in this retrospective study: 30 for the high VAT/SAT ratio group; 28 for the VAT/SAT low group. Multiple logistic regression analysis showed the VAT/SAT ratio and pre-donor eGFR were associated with eGFR < 45 ml/min/1.73 m2. An increase in VAT/SAT ratio was associated independently with the incidence of decreased renal function.

Conclusion

This finding indicates that adipose tissue distribution is an important predictor of the outcome of living kidney transplantation in recipients.

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Acknowledgements

The authors thank the clinical laboratory technicians of Okayama University Hospital for their technical support.

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Authors and Affiliations

  1. Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Yosuke Mitsui, Takuya Sadahira, Motoo Araki, Yuki Maruyama, Koichiro Wada, Ryuta Tanimoto, Yasuyuki Kobayashi, Masami Watanabe, Toyohiko Watanabe & Yasutomo Nasu

Authors
  1. Yosuke Mitsui
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  2. Takuya Sadahira
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  3. Motoo Araki
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  4. Yuki Maruyama
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  5. Koichiro Wada
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  6. Ryuta Tanimoto
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  7. Yasuyuki Kobayashi
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  8. Masami Watanabe
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  9. Toyohiko Watanabe
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  10. Yasutomo Nasu
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Corresponding author

Correspondence to Takuya Sadahira.

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Conflict of interest

The authors have declared that no conflict of interest exists.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Ethical approval

This clinical study was approved by the Okayama University Institutional Review Board prior to study initiation (Registration No. 951).

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Cite this article

Mitsui, Y., Sadahira, T., Araki, M. et al. Clinical impact of abdominal fat distribution measured by 3-D computed tomography volumetry on post-transplant renal function in recipients after living kidney transplantation: a retrospective study. Clin Exp Nephrol 23, 415–424 (2019). https://doi.org/10.1007/s10157-018-1643-6

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  • DOI: https://doi.org/10.1007/s10157-018-1643-6

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