Night-time blood pressure and pulse wave velocity in dialysis patients
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Ambulatory blood pressure (ABP) monitoring and carotid-femoral pulse wave velocity (cfPWV) provide important cardiovascular risk information for dialysis patients. This study aims to evaluate the risk factors of cfPWV and the associations between ambulatory blood pressure, especially night-time blood pressure and cfPWV.
We conducted a cross-sectional study in patients on maintenance hemodialysis. ABP and cfPWV were measured on a midweek interdialytic day. Associations were determined using Pearson’s correlation analysis and multiple stepwise regression model.
Systolic BPs and pulse pressures, but not diastolic BPs, were significantly and positively associated with cfPWV. In a stepwise regression model, age, diabetes mellitus and all-period systolic BP were independently associated with cfPWV. When day-time and night-time BPs were included in the analysis, respectively, only night-time systolic BP and age remained as independently associated with cfPWV.
Ambulatory BPs are potent associates of cfPWV and night-time systolic BP, rather than day-time BPs, is an independently predictor of cfPWV. Our results support the view that controlling of nocturnal hypertension provides a unique cardiovascular protection effect.
KeywordsAmbulatory blood pressure Blood pressure Hypertension PWV Dialysis
This work was supported by a grant from Science and Technology Bureau of Changzhou to Dr. Xiurong Li (Grant number CJ20160034).
Compliance with ethical standards
Conflict of interest
No conflicting relationship exists for any author.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee at which the studies were conducted (Approval number 2015 Science 006).
Informed consent was obtained from all individual participants included in the study.
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