Clinical and Experimental Nephrology

, Volume 22, Issue 1, pp 99–109 | Cite as

Off-pump versus on-pump coronary surgery in patients with chronic kidney disease: a meta-analysis

  • Yushu Wang
  • Sui Zhu
  • Peijuan Gao
  • Juteng Zhou
  • Qing ZhangEmail author
Original article



Patients with chronic kidney disease (CKD) have worse adverse cardiovascular outcomes after coronary artery bypass grafting (CABG). However, the adverse cardiovascular outcomes between off-pump coronary artery bypass grafting (OPCAB) versus on-pump coronary artery bypass grafting (ONCAB) in these patients have been a subject of debate.


We undertook a comprehensive literature search of PubMed, Embase, and the Cochrane Library database to identify all relevant studies comparing techniques between OPCAB and ONCAB in CKD patients. We pooled the odds ratios (ORs) and hazard ratios (HRs) from individual studies and conducted heterogeneity, quality assessment, and publication bias analyses.


This meta-analysis includes 17 studies with 201,889 patients. In CKD patients, OPCAB was associated with significantly lower early mortality as compared to ONCAB (OR 0.88; 95% CI 0.82–0.93; p < 0.0001). OPCAB was associated with decreased risk of atrial fibrillation (OR 0.57; 95% CI 0.34–0.97; p = 0.04), cerebrovascular accident (OR 0.46; 95% CI 0.22–0.95; p = 0.04), blood transfusion (OR 0.20; 95% CI 0.08–0.49; p = 0.0005), pneumonia, prolonged ventilation, and shorter hospital stays. No difference was found regarding long-term survival (HR 1.08; 95% CI 0.86–1.36; p = 0.51) or myocardial infarction (OR 0.65; 95% CI 0.30–1.38; p = 0.26).


Compared with ONCAB, OPCAB is associated with superior postoperative morbidity and the early mortality in CKD patients. Long-term survival is comparable between the two surgical revascularizations.


Off-pump coronary artery bypass grafting On-pump coronary artery bypass grafting Chronic kidney disease Coronary heart disease 


Compliance with ethical standards

Conflict of interest

The authors have declared that no conflict of interest exists.



Human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Japanese Society of Nephrology 2017

Authors and Affiliations

  • Yushu Wang
    • 1
  • Sui Zhu
    • 2
  • Peijuan Gao
    • 3
  • Juteng Zhou
    • 1
  • Qing Zhang
    • 1
    Email author
  1. 1.Department of Cardiology, West China HospitalSichuan UniversityChengduChina
  2. 2.Department of Epidemiology and Biostatistics, School of Public HealthSichuan UniversityChengduChina
  3. 3.Department of Nephrology, West China HospitalSichuan UniversityChengduChina

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