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Aichi cohort study of the prognosis in patients newly initiated into dialysis (AICOPP): baseline characteristics and trends observed in diabetic nephropathy

Clinical and Experimental Nephrology volume 20, pages 795–807 (2016)Cite this article

Abstract

Background

Over 300,000 patients receive maintenance dialysis in Japan; managing these patients is extremely important. This study aimed to report on prior management of chronic kidney diseases and prognostication after dialysis initiation.

Patients and methods

Seventeen institutions participated in the Aichi cohort study of prognosis in patients newly initiated into dialysis and recruited patients over a period of 2 years. Exclusion criteria were (1) patients under 20 years; (2) patients who died before hospital discharge; and (3) patients who could not provide consent.

Result

Here, we showed data on dialysis initiation time. Of 1524 patients with mean age of 67.5 ± 13.0 years, 659 patients were put on dialysis following diabetic nephropathy diagnosis. At dialysis initiation time, creatinine and estimated glomerular filtration rate levels were 8.97 ± 3.21 mg/dl and 5.45 ± 2.22 ml/min/1.73 m2, respectively. Medications taken were angiotensin II receptor blockers in 866; angiotensin-converting enzyme inhibitors in 135; calcium antagonist in 1202; and diuretics, alone or in combination, in 1059. Among patients with diabetic nephropathy, many had increased body weight and systolic blood pressure and were taking loop and thiazide diuretics at dialysis initiation time. Many patients with diabetic nephropathy had coronary artery disease and percutaneous coronary intervention.

Conclusion

Many patients with diabetic nephropathy who registered for this study had coronary artery disease and problems with excess body fluid. Further analyses may clarify how underlying conditions and disease management before and after dialysis initiation affect prognosis.

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Acknowledgments

We acknowledge the support of the following investigators, who are members of AICOPP, who participated in this study: Hirofumi Tamai (Anjo Kosei Hospital), Tomohiko Naruse (Kasugai Municipal Hospital), Kei Kurata (Tosei General Hospital), Hideto Oishi (Komaki City Hospital), Isao Aoyama (Social Insurance Chukyo Hospital), Hiroshi Ogawa (Shinseikai Daiichi Hospital), Hiroko Kushimoto (Chita City Hospital), Hideaki Shimizu (Chubu-Rosai Hospital), Junichiro Yamamoto (Tsushima City Hospital), Hisashi Kurata (Toyota Kosei Hospital), Taishi Yamakawa (Toyohashi Municipal Hospital), Takaaki Yaomura (Nagoya Medical Center), Hirotake Kasuga (Nagoya Kyouritsu Hospital), Shizunori Ichida (Japanese Red Cross Nagoya Daiichi Hospital), Noritoshi Kato (Nagoya University Graduate School of Medicine), Shigehisa Koide (Fujita Health University Hospital), and Yukio Yuzawa (Fujita Health University Hospital).

Author information

Affiliations

  1. Department of Nephrology, Anjo Kosei Hospital, Aichi, 28 Higashihirokute, Anjo-cho, Anjo, 446-8602, Japan

    Manabu Hishida, Hirofumi Tamai, Takatoshi Morinaga, Michitaka Maekawa, Takafumi Aoki, Hidetaka Tomida, Shintaro Komatsu & Tomoaki Kamiya

  2. Department of Nephrology, Nagoya University Graduate School of Medicine, Aichi, Japan

    Shoichi Maruyama & Seiichi Matsuo

  3. Japanese Red Cross Nagoya Daini Hospital, Aichi, Japan

    Daijo Inaguma

Authors
  1. Manabu Hishida
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  2. Hirofumi Tamai
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  3. Takatoshi Morinaga
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  4. Michitaka Maekawa
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  5. Takafumi Aoki
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  6. Hidetaka Tomida
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  7. Shintaro Komatsu
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  8. Tomoaki Kamiya
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  9. Shoichi Maruyama
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  10. Seiichi Matsuo
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  11. Daijo Inaguma
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Corresponding author

Correspondence to Hirofumi Tamai.

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Additional information

Manabu Hishida, Hirohumi Tamai, Takatoshi Morinaga, Michitaka Maekawa, Takahumi Aoki, Hidetaka Tomida, Shintaro Komatsu, Tomoaki Kamiya, Shoichi Maruyama, Seiichi Matsuo, Daijo Inaguma, and the Aichi cohort study of prognosis in patients newly initiated into dialysis study group.

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Cite this article

Hishida, M., Tamai, H., Morinaga, T. et al. Aichi cohort study of the prognosis in patients newly initiated into dialysis (AICOPP): baseline characteristics and trends observed in diabetic nephropathy. Clin Exp Nephrol 20, 795–807 (2016). https://doi.org/10.1007/s10157-015-1206-z

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  • DOI: https://doi.org/10.1007/s10157-015-1206-z

Keywords

  • Dialysis
  • Cardiovascular disease
  • Heart failure
  • Diabetic nephropathy
  • AICOPP
  • Cohort