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Glomerular basement membrane (GBM) abnormalities are worth pursuing

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References

  1. Kanwar YS. Biophysiology of glomerular filtration and proteinuria. Lab Invest. 1984;51(1):7–21.

    CAS  PubMed  Google Scholar 

  2. Farquhar MG. The glomerular basement membrane: not gone, just forgotten. J Clin Invest. 2006;116(8):2090–3.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Tryggvason K. Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm. J Am Soc Nephrol. 1999;10(11):2440–5.

    CAS  PubMed  Google Scholar 

  4. Jarad G, Cunningham J, Shaw AS, Miner JH. Proteinuria precedes podocyte abnormalities in Lamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier. J Clin Invest. 2006;116(8):2272–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Gao Y, Liu S, Huang J, Guo W, Chen J, et al. The ECM-cell interaction of cartilage extracellular matrix on chondrocytes. Biomed Res Int. 2014;2014:648459. doi:10.1155/2014/64845.

    PubMed Central  PubMed  Google Scholar 

  6. Bornstein P, Sage EH. Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol. 2002;14(5):608–16.

    Article  CAS  PubMed  Google Scholar 

  7. Jun JI, Lau LF. Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nat Rev Drug Discov. 2011;10(12):945–63. doi:10.1038/nrd3599.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Neill T, Schaefer L, Iozzo RV. Instructive roles of extracellular matrix on autophagy. Am J Pathol. 2014;. doi:10.1016/j.ajpath.2014.05.010.

    PubMed  Google Scholar 

  9. Zhou J, Reeders ST. The alpha chains of type IV collagen. Contrib Nephrol. 1996;117:80–104.

    CAS  PubMed  Google Scholar 

  10. Kruegel J, Rubel D, Gross O. Alport syndrome–insights from basic and clinical research. Nat Rev Nephrol. 2013;9(3):170–8. doi:10.1038/nrneph.2012.259.

    Article  CAS  PubMed  Google Scholar 

  11. Masuda Y, Yamanaka N, Ishikawa A, Kataoka M, Arai T, et al. Glomerular basement membrane injuries in IgA nephropathy evaluated by double immunostaining for α5(IV) and α2(IV) chains of type IV collagen and low-vacuum scanning electron microscopy. Clin Exp Nephrol. 2014;. doi:10.1007/s10157-014-1008-8.

    PubMed  Google Scholar 

  12. Sanna-Cherchi S, Carnevali ML, Martorana D, Cravedi P, Maggiore U, et al. Alterations of type IV collagen alpha chains in patients with chronic acquired glomerulopathies: mRNA levels, protein expression and urinary loss. Am J Nephrol. 2007;27(2):129–37.

    Article  CAS  PubMed  Google Scholar 

  13. Kim Y, Butkowski R, Burke B, Kleppel MM, Crosson J, et al. Differential expression of basement membrane collagen in membranous nephropathy. Am J Pathol. 1991;139(6):1381–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  14. Kamimura H, Honda K, Nitta K, Horita S, Kobayashi H, et al. Glomerular expression of alpha2(IV) and alpha5(IV) chains of type IV collagen in patients with IgA nephropathy. Nephron. 2002;91(1):43–50.

    Article  CAS  PubMed  Google Scholar 

  15. Horita S, Nitta K, Honda K, Kobayashi H, Uchida K, et al. A case of IgA nephropathy with split reduction of alpha5(V) chain of type IV collagen in glomerular basement membrane. Nephron. 1998;80(4):482–3.

    Article  CAS  PubMed  Google Scholar 

  16. Suh JH, Miner JH. The glomerular basement membrane as a barrier to albumin. Nat Rev Nephrol. 2013;9(8):470–7. doi:10.1038/nrneph.2013.109.

    Article  CAS  PubMed  Google Scholar 

  17. Pihlajaniemi T. Molecular properties of the glomerular basement membrane. Contrib Nephrol. 1996;117:46–79.

    CAS  PubMed  Google Scholar 

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Conflict of interest

All authors have declared no competing interests.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Aichi Medical University School of Medicine, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan

    Junko Takagi & Hiroyuki Morita

  2. Advanced Medical Research Center, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan

    Koji Kimata

Authors
  1. Junko Takagi
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  2. Hiroyuki Morita
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  3. Koji Kimata
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Corresponding author

Correspondence to Hiroyuki Morita.

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Takagi, J., Morita, H. & Kimata, K. Glomerular basement membrane (GBM) abnormalities are worth pursuing. Clin Exp Nephrol 19, 329–330 (2015). https://doi.org/10.1007/s10157-014-1025-7

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  • DOI: https://doi.org/10.1007/s10157-014-1025-7

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