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Hypoadiponectinemia correlates with arterial stiffness in kidney transplantation patients

Clinical and Experimental Nephrology volume 19, pages 534–541 (2015)Cite this article

Abstract

Background

Adiponectin is a fat-derived hormone produced and secreted exclusively by adipocytes that have anti-atherosclerotic effects. The aim of this study was to evaluate the relationship between fasting serum adiponectin levels and arterial stiffness among kidney transplant (KT) patients.

Methods

Fasting blood samples were obtained from 69 KT patients. Brachial–ankle pulse wave velocity (baPWV) was measured in the right or left brachial artery to the ankle segments using an automatic pulse wave analyzer. Plasma adiponectin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Left or right baPWV values of >14.0 m/s were used to define the high arterial stiffness group.

Results

Thirty-five KT patients (35/69; 50.7 %) were defined in high arterial stiffness group. Diabetes (P = 0.013), smoking (P = 0.001), KT duration (P < 0.001), body weight (P = 0.013), waist circumference (P = 0.013), body mass index (P = 0.001), fasting glucose (P = 0.013), systolic blood pressure (P < 0.001), diastolic blood pressure (P = 0.008), and pulse pressure (P = 0.003) were higher, while serum adiponectin level (P = 0.004) was lower in high arterial stiffness group compared with low arterial stiffness group. Multivariate logistic regression analysis showed that adiponectin (odds ratio 0.90, 95 % confidence interval 0.81–0.99, P = 0.034) was still the independent predictors of arterial stiffness among the KT patients.

Conclusion

Serum fasting adiponectin level was inversely associated with arterial stiffness among KT patients.

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Acknowledgments

This study was supported by a grant from Buddhist Tzu Chi General Hospital, Hualien, Taiwan (TCRD101-06).

Conflict of interest

All the authors have declared that there are no conflicts of interests.

Author information

Affiliations

  1. Division of Nephrology, Buddhist Tzu Chi General Hospital, and School of Medicine, Tzu Chi University, No. 707, Section 3, Chung-Yang Raod, Hualien, Taiwan

    Bang-Gee Hsu

  2. Department of Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan

    Guan-Jin Ho & Yen-Cheng Chen

  3. Department of Surgery, Buddhist Tzu Chi General Hospital, and School of Medicine, Tzu Chi University, Hualien, Taiwan

    Ming-Che Lee

  4. Department of Nursing, Tzu Chi College of Technology, Hualien, Taiwan

    Chung-Jen Lee

Authors
  1. Guan-Jin Ho
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  2. Ming-Che Lee
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  3. Chung-Jen Lee
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  4. Yen-Cheng Chen
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  5. Bang-Gee Hsu
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Corresponding author

Correspondence to Bang-Gee Hsu.

Additional information

G. J. Ho and M. C. Lee contributed equally to this study.

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Cite this article

Ho, GJ., Lee, MC., Lee, CJ. et al. Hypoadiponectinemia correlates with arterial stiffness in kidney transplantation patients. Clin Exp Nephrol 19, 534–541 (2015). https://doi.org/10.1007/s10157-014-1010-1

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  • DOI: https://doi.org/10.1007/s10157-014-1010-1

Keywords

  • Kidney transplantation
  • Adiponectin
  • Arterial stiffness
  • Brachial–ankle pulse wave velocity