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The influences of larger physical constitutions including obesity on the amount of urine protein excretion in primary glomerulonephritis: research of the Japan Renal Biopsy Registry

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Abstract

Background

This study aimed to describe the influences of larger physical constitutions including obesity on the amount of urine protein excretion (AUPE) in primary glomerulonephritis. The distinct effects on the AUPE in various types of glomerulonephritis were evaluated.

Methods

Using the database of the Japan Renal Biopsy Registry (J-RBR) from 2007 to 2010, 4060 cases with primary glomerulonephritis including MCNS, FSGS, MN, MPGN, IgAN, and non-IgA were reviewed. The AUPEs were compared between high and low Body Mass Index (BMI) groups, and larger and smaller body surface area (BSA) groups using the indexes of BMI 25.0 kg/m2 and BSA 1.73 m2 in all cases and in each histological group. Multivariable analysis was performed to evaluate the predominant contributors to the AUPE.

Results

The larger physical constitution groups (BMI ≥25.0 kg/m2 or BSA ≥1.73 m2) had significantly higher AUPEs in all cases with primary glomerulonephritis. When compared in each histological group, the mean AUPEs were significantly higher in the larger physical constitution groups, excluding the FSGS and non-IgA groups. Multiple regression analysis revealed that the significant contributors to the AUPE were BMI and BSA in MCNS and MN, whereas BMI and BSA were not significant and mean blood pressure and serum creatinine were significant in FSGS and non-IgA.

Conclusion

Larger physical constitutions including obesity had a significant impact on the increase in the AUPE in primary glomerulonephritis, especially in MCNS and MN. However, FSGS and non-IgA were distinct for having blood pressure and renal dysfunction as possibly the major causes of proteinuria.

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Acknowledgments

The authors are grateful for the help and support from the J-RBR committee and all of the colleagues who participated in the J-RBR governed by Japanese Society of Nephrology. This study was supported by a grant-in-aid from the Research Group on Progressive Renal Disease from the Ministry of Health, Labor and Welfare, Japan.

Conflict of interest

The authors have declared that no Conflict of interest exists.

Author information

Authors and Affiliations

  1. Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Yuriko Yonekura, Shunsuke Goto & Shinichi Nishi

  2. Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata, Okayama, 700-8558, Japan

    Hitoshi Sugiyama

  3. Department of Pathology, Clinical Research Center, National Hospital Organization Chiba East National Hospital, 673 Nitona, Chiba, Chiba, 260-8712, Japan

    Hiroshi Kitamura

  4. Department of Nephrology, Kanazawa Medical University School of Medicine, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan

    Hitoshi Yokoyama

Authors
  1. Yuriko Yonekura
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  2. Shunsuke Goto
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  3. Hitoshi Sugiyama
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  4. Hiroshi Kitamura
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  5. Hitoshi Yokoyama
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  6. Shinichi Nishi
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Corresponding author

Correspondence to Shinichi Nishi.

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Yonekura, Y., Goto, S., Sugiyama, H. et al. The influences of larger physical constitutions including obesity on the amount of urine protein excretion in primary glomerulonephritis: research of the Japan Renal Biopsy Registry. Clin Exp Nephrol 19, 359–370 (2015). https://doi.org/10.1007/s10157-014-0993-y

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  • DOI: https://doi.org/10.1007/s10157-014-0993-y

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