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Final adult height in kidney recipients who underwent highly successful transplantation as children: a single-center experience

Clinical and Experimental Nephrology volume 18, pages 515–520 (2014)Cite this article

Abstract

Background

Achieving a normal final adult height (FH) remains a challenge in the field of pediatric kidney transplantation (KTx). To examine the optimal approach to assuring normal FH following KTx, we retrospectively examined the post-transplant growth and FH of pediatric KTx recipients.

Methods

Since the relevant factors affecting the FH of children following KTx are multifactorial and notably complex, KTx recipients with persistent good graft function and successful steroid minimization until FH attainment were selected for this study.

Results

Thirteen patients were enrolled in this study. The mean estimated glomerular filtration rate was 72.1 ± 15.3 ml/min/1.73 m2, and the mean corticosteroid dose was 0.05 ± 0.05 mg/kg on alternate days at the time of FH attainment. Despite highly successful KTx, four (30.8 %) patients (one who underwent KTx before puberty and three during puberty) showed a decrease in the height standard deviation score (hSDS) from the time of KTx until FH attainment. Moreover, of these, two male patients had an FH with an SD <−2.

Conclusion

FH remained suboptimal despite highly successful KTx. Not only highly successful KTx but also further treatment such as steroid avoidance, early steroid withdrawal or using rhGH might be necessary to assure a normal FH in some pubertal patients.

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Acknowledgments

The authors gratefully acknowledge Drs. Masataka Hisano, Kiyonobu Ishizuka and Noriko Sugawara, Department of Pediatric Nephrology, Tokyo Women’s Medical University, for providing care for these patients.

Conflict of interest

The authors have declared that no conflict of interest exists.

Author information

Affiliations

  1. Department of Pediatrics, Koseiren Hiroshima General Hospital, 1-3-3 Zigozen, Hatsukaichi-shi, Hiroshima, 738-8503, Japan

    Hiroshi Fujii

  2. Department of Pediatric Nephrology, Tokyo Women’s Medical University, School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Hiroko Chikamoto, Yuko Akioka & Motoshi Hattori

Authors
  1. Hiroshi Fujii
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  2. Hiroko Chikamoto
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  3. Yuko Akioka
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  4. Motoshi Hattori
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Corresponding author

Correspondence to Motoshi Hattori.

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Fujii, H., Chikamoto, H., Akioka, Y. et al. Final adult height in kidney recipients who underwent highly successful transplantation as children: a single-center experience. Clin Exp Nephrol 18, 515–520 (2014). https://doi.org/10.1007/s10157-013-0842-4

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  • DOI: https://doi.org/10.1007/s10157-013-0842-4

Keywords

  • Kidney transplantation
  • Children
  • Final adult height