Clinical and Experimental Nephrology

, Volume 17, Issue 6, pp 751–764 | Cite as

Vasopressin and the regulation of aquaporin-2

  • Justin L. L. Wilson
  • Carlos A. Miranda
  • Mark A. Knepper
Review Article

Abstract

Water excretion is regulated in large part through the regulation of osmotic water permeability of the renal collecting duct epithelium. Water permeability is controlled by vasopressin through regulation of the water channel, aquaporin-2 (AQP2). Two processes contribute: (1) regulation of AQP2 trafficking to the apical plasma membrane; and (2) regulation of the total amount of the AQP2 protein in the cells. Regulation of AQP2 abundance is defective in several water-balance disorders, including many polyuric disorders and the syndrome of inappropriate antidiuresis. Here we review vasopressin signaling in the renal collecting duct that is relevant to the two modes of water permeability regulation.

Keywords

Vasopressin Trafficking Transcription Polyuria Hyponatremia SIADH 

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Copyright information

© Japanese Society of Nephrology (outside the USA) 2013

Authors and Affiliations

  • Justin L. L. Wilson
    • 1
  • Carlos A. Miranda
    • 1
  • Mark A. Knepper
    • 1
  1. 1.Epithelial Systems Biology Laboratory, Systems Biology Center, National Heart, Lung, and Blood InstituteNational Institutes of HealthBethesdaUSA

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