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Polymorphism in the human matrix Gla protein gene is associated with the progression of vascular calcification in maintenance hemodialysis patients

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Abstract

Background

Matrix Gla protein (MGP) is one of the important proteins inhibiting vascular calcification (VC). Single nucleotide polymorphisms (SNPs) located in the promoter and coding regions of the MGP gene affect the transcriptional activity. In this study, we investigated the relationship between the SNPs and progression of VC in patients undergoing maintenance hemodialysis (MHD).

Methods

This was a retrospective, longitudinal cohort study of 134 MHD patients whose VC could be followed by multi-detector computed tomography (MDCT) examinations. MGP-SNPs (T-138C, rs1800802 and G-7A, rs1800801) were determined. The progression speed of VC was examined by plotting the abdominal aortic calcium volume scores.

Results

The progression speed of VC of patients with the CC genotype of T-138C was significantly slower than that of patients with the CT or TT genotype. Multiple regression analysis showed that CT/TT genotype, greater age at the beginning of MHD, male sex, high levels of calcium × phosphate, low levels of high-density lipoprotein cholesterol, high levels of low-density lipoprotein cholesterol, low levels of ferritin and non-use of angiotensin II receptor blockers were significantly associated with progression of VC.

Conclusions

The MGP-138CC genotype may be associated with slower progression of VC in MHD patients. The genotype of the MGP gene will be a genomic biomarker that is predictive of VC progression.

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Acknowledgments

The authors thank A. Sakurai, T. Sasaki, and S. Hayashi for their technical support. This study was supported in part by a Grant-in-Aid for Diabetic Nephropathy, Research from the Ministry of Health, Labour and Welfare of Japan and a grant from The Kidney Foundation, Japan (JKFB10-28 and JKF10-2).

Conflict of interest

The authors have declared that no conflict of interest exists.

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Authors and Affiliations

  1. The Department of Nephrology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, 770-8503, Japan

    Kazuhiro Yoshikawa, Hideharu Abe, Tatsuya Tominaga, Seiji Kishi, Motokazu Matsuura, Kojiro Nagai & Toshio Doi

  2. The Department of Kidney Disease, Dialysis and Kidney Transplantation, Kawashima Hospital, Tokushima, Japan

    Masayuki Nakamura, Kenji Tsuchida & Jun Minakuchi

Authors
  1. Kazuhiro Yoshikawa
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  2. Hideharu Abe
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  3. Tatsuya Tominaga
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  6. Motokazu Matsuura
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  10. Toshio Doi
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Correspondence to Hideharu Abe.

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Yoshikawa, K., Abe, H., Tominaga, T. et al. Polymorphism in the human matrix Gla protein gene is associated with the progression of vascular calcification in maintenance hemodialysis patients. Clin Exp Nephrol 17, 882–889 (2013). https://doi.org/10.1007/s10157-013-0785-9

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  • DOI: https://doi.org/10.1007/s10157-013-0785-9

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