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Obesity and chronic kidney disease in patients with chronic heart failure: an insight from the China Heart Survey

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Abstract

Background

Obesity and decreased kidney function have been shown to be prevalent in Western patients with heart failure; however, whether this phenomenon exists in Chinese patients with chronic heart failure (CHF) is not known.

Methods and results

One thousand and nine patients with CHF from the China Heart Survey were assessed. The prevalence of chronic kidney disease (CKD) was 34.2%, and there was a stepwise increase in the prevalence of CKD with New York Heart Association (NYHA) classes (P < 0.001). Moreover, patients with CKD had a significantly elevated risk for developing severe extent of CHF (OR = 1.69, 95% CI: 1.27–2.24, P < 0.001). The prevalence of obesity and central obesity was 35.7% and 62.5%, respectively. Notably, there was a downward trend in the prevalence of obesity with advanced NYHA classes (trend test, P = 0.003). Multivariate analysis further supported the finding that obesity, but not central obesity, was inversely associated with the extent of CHF (OR = 0.72, 95% CI: 0.55–0.94, P = 0.017).

Conclusions

Renal dysfunction is common in Chinese patients with CHF and is independently associated with advanced NYHA classes. Obesity was inversely associated with the extent of CHF, which further supports the notion that obesity confers improved prognosis in patients with heart failure.

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Acknowledgments

The involvement of the study coordinators and their hospitals are acknowledged.

Conflict of interest

None declared.

Author information

Authors and Affiliations

  1. Clinical Research Institute, School of Public Health, Fudan University, 130 Dong-An Rd., Shanghai, 200032, China

    Hao Liu, Jinming Yu & Qingwu Jiang

  2. Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, Shanghai, 200032, China

    Hao Liu, Jinming Yu & Qingwu Jiang

  3. Tangdu Hospital, The Fourth Military Medical University, Xi’an, 710038, China

    Hong Shi

  4. Department of Preventive Medicine, Tongji University School of Medicine, Shanghai, 200092, China

    Fang Chen

  5. Department of Cardiology, People’s Hospital, Peking University, Beijing, 100044, China

    Dayi Hu

Authors
  1. Hao Liu
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  2. Hong Shi
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  3. Jinming Yu
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  4. Fang Chen
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  5. Qingwu Jiang
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  6. Dayi Hu
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Corresponding author

Correspondence to Jinming Yu.

Additional information

H. Liu and H. Shi contributed equally to this work and should be considered co-first authors.

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Liu, H., Shi, H., Yu, J. et al. Obesity and chronic kidney disease in patients with chronic heart failure: an insight from the China Heart Survey. Clin Exp Nephrol 15, 522–528 (2011). https://doi.org/10.1007/s10157-011-0443-z

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  • DOI: https://doi.org/10.1007/s10157-011-0443-z

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