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Searching for novel intercellular signal-transducing molecules in the kidney and their clinical application

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Abstract

In this review, isolation and characterization of several kidney-derived molecules are described, namely carbonic anhydrase XIV, cysteine-rich protein 61, and kidney–liver-specific immunoglobulin-like protein. Features of neutrophil gelatinase-associated lipocalin (LCN2 or human neutrophil lipocalin) as a kidney differentiation inducer and renal injury biomarker and also as an iron-carrier protein are also summarized. Furthermore, the concepts of forest fire theory and the biology of siderophore-binding proteins are discussed.

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Acknowledgments

Unfortunately we could not describe all the contributors and original papers in Ngal research. We would especially like to acknowledge Drs. J. Barasch (Columbia University), P. Devarajan (Cincinnati Children’s Hospital), and M. Kasahara, H. Yokoi, K. Sawai, and T. Kuwabara (Kyoto University) for their collaboration.

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Authors and Affiliations

  1. Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan

    Kiyoshi Mori, Masashi Mukoyama & Kazuwa Nakao

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  1. Kiyoshi Mori
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  2. Masashi Mukoyama
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  3. Kazuwa Nakao
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Correspondence to Kiyoshi Mori.

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Mori, K., Mukoyama, M. & Nakao, K. Searching for novel intercellular signal-transducing molecules in the kidney and their clinical application. Clin Exp Nephrol 14, 523–527 (2010). https://doi.org/10.1007/s10157-010-0320-1

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  • DOI: https://doi.org/10.1007/s10157-010-0320-1

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