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Pulmonary renal syndrome associated with Wegener’s granulomatosis: a case report and review of literature

Clinical and Experimental Nephrology volume 14, pages 80–84 (2010)Cite this article

Abstract

Pulmonary renal syndromes are rare but serious complications of systemic vasculitis. The majority of these cases are related to ANCA-associated vasculitis. These syndromes represent a combination of diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis. Here we report a case of 21-year-old female with a clinical picture of community-acquired pneumonia that rapidly evolved to pulmonary hemorrhage and acute renal failure. Combined pulse steroid treatment, immunosuppressive treatment, and plasmapheresis were instituted and resulted in the improvement of the patient. The diagnosis of Wegener’s granulomatosis was established based on the clinical and serological findings (positive cANCA). Here we review the relevant literature on pulmonary renal syndromes associated with Wegener’s granulomatosis and discuss their diverse clinicopathologic features.

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Acknowledgment

Financial support and sources of funding were not received.

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Affiliations

  1. Assir Central Hospital, Abha, Kingdom of Saudi Arabia

    Ali A. Al bshabshe, Hussein Al-Khalidy, Hyder A. Omer, Daefullah H. Al-Amri & Aymen Hamad

  2. Al-Azhar University, Assuit, Egypt

    Saad-Rezk Abdulwahed

  3. Assuit University, Assuit, Egypt

    Mahmoud R. Hussein

  4. Department of Pathology, Faculty of Medicine, Assuit University, Assuit, Egypt

    Mahmoud R. Hussein

Authors
  1. Ali A. Al bshabshe
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  2. Hussein Al-Khalidy
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  3. Hyder A. Omer
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  4. Daefullah H. Al-Amri
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  5. Aymen Hamad
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  6. Saad-Rezk Abdulwahed
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  7. Mahmoud R. Hussein
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Corresponding author

Correspondence to Mahmoud R. Hussein.

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Al bshabshe, A.A., Al-Khalidy, H., Omer, H.A. et al. Pulmonary renal syndrome associated with Wegener’s granulomatosis: a case report and review of literature. Clin Exp Nephrol 14, 80–84 (2010). https://doi.org/10.1007/s10157-009-0223-1

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  • DOI: https://doi.org/10.1007/s10157-009-0223-1

Keywords

  • Wegener’s granulomatosis
  • Plasmapheresis
  • Pulmonary renal syndrome