Abstract
Membranous glomerulonephritis is most often idiopathic, but it can be secondary to systemic lupus erythematosus, viral hepatitis, and drugs. A number of malignancies have also been associated with membranous glomerulonephritis, although a causal link has not been established yet. A young patient with lymphangioleiomyomatosis is described who developed massive proteinuria and was found to have membranous glomerulonephritis on renal biopsy. There were many pathological features and some clinical features that suggested the patient also suffered from systemic lupus erythematosus.
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Chu SC, Horiba K, Usuki J, et al. Comprehensive evaluation of 35 patients with lymphangioleiomyomatosis. Chest. 1999;115:1041–52.
Taylor JR, Ryu J, Colby TV, Raffin TA. Lymphangioleiomyomatosis: clinical course in 32 patients. N Engl J Med. 1990;323:1254–60.
Hancock E, Osborne J. Lymphangioleiomyomatosis: a review of the literature. Respir Med. 2002;96:1–6.
Johnson S. Rare diseases. 1. Lymphangioleiomyomatosis: clinical features, management and basic mechanisms. Thorax. 1999;54:254–64.
Johnson SR, Tattersfield AE. Clinical experience of lymphangioleiomyomatosis in the UK. Thorax. 2000;55:1025–57.
Bernstein SM, Newell JD Jr, Adamczyk D, Mortenson RL, King TE Jr, Lynch DA. How common are renal angiomyolipomas in patients with pulmonary lymphangiomyomatosis? Am J Respir Crit Care Med. 1995;152:2138–43.
Maziak DE, Kesten S, Rappaport DC, Maurer J. Extrathoracic angiomyolipomas in lymphangioleiomyomatosis. Eur Respir J. 1996;9:402–5.
Crino PB, Nathanson KL, Henske EP. Tuberous sclerosis complex. N Engl J Med. 2006;355:1345.
Rebecca A, De Pauw, Johan R, et al. Renal Angiomyolipoma in Association with Pulmonary Lymphangioleiomyomatosis. Am J Kidney Dis. 2003;41:877–83.
Kuroki A, Shibata T, Honda H, et al. Glomerular and serum IgG subclasses in diffuse proliferative lupus nephritis, membranous lupus nephritis, and idiopathic membranous nephropathy. Intern Med. 2002;41:936–42.
Doi T, Mayumi M, Kanatsu K, et al. Distribution of IgG subclasses in membranous nephropathy. Clin Exp Immunol. 1984;58:57–62.
Roberts JL, Wyatt RJ, Schwartz MM, et al. Differential characteristics of immune-bound antibodies in diffuse proliferative and membranous forms of lupus glomerulonephritis. Clin Immunol Immunopathol. 1983;29:223–41.
Haas M. IgG subclass deposits in glomeruli of lupus and nonlupus membranous nephropathies. Am J Kidney Dis. 1994;23:358–64.
Imai H, Hamai K, Komatsuda A, et al. IgG subclasses in patients with membranoproliferative glomerulonephritis, membranous nephropathy, and lupus nephritis. Kidney Int. 1997;51:270–6.
Ohtani H, Wakui H, Komatsuda A, et al. Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy. Nephrol Dial Transplant. 2004;19:574–9.
Costanza ME, Pinn V, Schwartz RS, Nathanson L. Carcinoembryonic antigen-antibody complexes in a patient with colonic carcinoma and nephrotic syndrome. N Engl J Med. 1973;289:520–2.
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Sam, R., Khalid, S., Brecklin, C. et al. A case of lymphangioleiomyomatosis with membranous nephropathy and likely systemic lupus. Clin Exp Nephrol 13, 166–169 (2009). https://doi.org/10.1007/s10157-008-0083-0
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DOI: https://doi.org/10.1007/s10157-008-0083-0