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Carbonic-adsorbent AST-120 reduces overload of indoxyl sulfate and the plasma level of TGF-β1 in patients with chronic renal failure

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Abstract

Background

We previously reported a significant increase in plasma TGF-β1 in patients with chronic renal failure (CRF). Progression of CRF may be caused by persistent renal production of TGF-β1. In CRF rat models, an oral carbonic absorbent (AST-120) reduces the expression of the TGF-β1 gene in the kidney, and delays the progression of CRF, in part by alleviating the overload of indoxyl sulfate. The aim of this study was to evaluate the effect of AST-120 on plasma levels of indoxyl sulfate and TGF-β1 in CRF patients.

Methods

Ten CRF patients (aged 59.3 ± 9.5 years, 5 men, serum creatinine 4.37 ± 1.72 mg/dl) were enrolled in this study. All patients maintained a regular dietary therapy and the same medication throughout the study. AST-120 was added at a dose of 6 g/day. Parameters including the slope of the reciprocal of the serum creatinine – time plot, plasma indoxyl sulfate level, and plasma and urinary levels of TGF-β1 were compared before and after the treatment with AST-120. The mean observation periods before and after the treatment were 9.7 ± 2.8 and 6.5 ± 2.9 months, respectively.

Results

Administration of AST-120 significantly reduced the plasma levels of indoxyl sulfate (1.42 ± 1.50 vs. 1.26 ± 1.40 mg/dl, P < 0.05) and TGF-β1 (17.9 ± 7.2 vs. 10.6 ± 4.7 ng/ml, P < 0.05) and improved the slope of the reciprocal of serum creatinine (−0.061 ± 0.041 vs. −0.032 ± 0.055 dl/mg/year, P < 0.05).

Conclusions

These results support the notion that indoxyl sulfate and TGF-β1 may be involved in the progression of CRF, and that the oral adsorbent AST-120 may suppress the progression, at least in part, by reducing overproduction of TGF-β1.

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Authors and Affiliations

  1. Department of Nephrology, Kurume University School of Medicine, Kurume, Fukuoka, 830-0011, Japan

    Shuji Iida, Keisuke Kohno, Junko Yoshimura, Seiji Ueda, Michiaki Usui, Hiroshi Miyazaki, Hidemi Nishida, Kiyoshi Tamaki & Seiya Okuda

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  1. Shuji Iida
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  2. Keisuke Kohno
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  3. Junko Yoshimura
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  4. Seiji Ueda
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  5. Michiaki Usui
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  6. Hiroshi Miyazaki
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  7. Hidemi Nishida
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  8. Kiyoshi Tamaki
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  9. Seiya Okuda
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Correspondence to Kiyoshi Tamaki.

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Iida, S., Kohno, K., Yoshimura, J. et al. Carbonic-adsorbent AST-120 reduces overload of indoxyl sulfate and the plasma level of TGF-β1 in patients with chronic renal failure. Clin Exp Nephrol 10, 262–267 (2006). https://doi.org/10.1007/s10157-006-0441-8

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  • DOI: https://doi.org/10.1007/s10157-006-0441-8

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