Skip to main content
SpringerLink
Log in

Performance of polysulfone membrane dialyzers and dialysate flow pattern

  • ORIGINAL ARTICLE
  • Published:
Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

Background

It is important to observe the flow pattern of dialysate when evaluating dialyzer function and developing the most appropriate design. We investigated dialysate flow through two polysulfone membrane dialyzers (TS-UL [Toray Medical] and APS-S [Asahi Medical]) by computed tomography (CT), with barium sulfate as the contrast medium. We also performed a clinical comparison of these two dialyzers.

Methods

For the in vitro experiment, after confirming the steady-state flow of mock blood (xanthan gum solution; 200 ml/min) and dialysate (500 ml/min), fresh dialysate, containing 5% (w/v) barium sulfate was perfused, and longitudinal CT scans of the dialyzer were obtained. Then the concentration of barium sulfate was measured (in Hounsfield units) in three fixed regions of interest. For the in vivo experiment, 12 patients on stable hemodialysis who had been using the APS-S for more than 1 month were switched to the TS-UL for 1 month and changes in various parameters were assessed.

Results

The distribution of dialysate was homogeneous on CT scans of the TS-UL, but not on scans of the APS-S. The dialysate concentration curves for the three regions of interest were similar with the TS-UL, but not with the APS-S. Clearance of urea nitrogen and albumin loss were both significantly higher with the TS-UL than with the APS-S. The decrease in alpha 1-microglobulin was larger with the TS-UL than with the APS-S, but not significantly.

Conclusions

Clearance of substances over a wide range of molecular weights was higher with the TS-UL than with the APS-S, and differences in the design of the dialysate compartment may have been involved in this feature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S Takesawa M Terasawa M Sakagami T Kobayashi H Hidai K Sakai (1988) ArticleTitleNondestructive evaluation by X-ray computed tomography of dialysate flow patterns in capillary dialyzers ASAIO Trans 34 794–9 Occurrence Handle3196601 Occurrence Handle1:STN:280:BiaD283hvVM%3D

    PubMed  CAS  Google Scholar 

  2. S Takesawa (1990) Imbalance of flow in whole dialyzers BibInstitutionalEditorNameThe Japanese Society for High-Performance Membranes (Eds) High-performance membranes for staff engaged in hemodialysis (in Japanese) Tokyoigakusha Tokyo 66–73

    Google Scholar 

  3. C Ronco A Brendolan G Cappelli M Ballestri P Inguaggiato L Fortunato et al. (1999) ArticleTitleIn vitro and in vivo evaluation of a new polysulfone membrane for hemodialysis. Reference methodology and clinical results. (Part 1: in vitro study) Int J Artif Organs 22 604–15 Occurrence Handle10532429 Occurrence Handle1:CAS:528:DyaK1MXntFOnur4%3D

    PubMed  CAS  Google Scholar 

  4. Y Sakai S Wada H Matsumoto T Suyama O Ohno I Anno (2003) ArticleTitleNondestructive evaluation of blood flow in a dialyzer using X-ray computed tomography J Artif Organs 6 197–204 Occurrence Handle14598104 Occurrence Handle10.1007/s10047-003-0228-6

    Article  PubMed  Google Scholar 

  5. C Ronco A Brendolan M Feriani M Milan P Conz A Lupi et al. (1992) ArticleTitleA new scintigraphic method to characterize ultrafiltration in hollow fiber dialyzers Kidney Int 41 1383–93 Occurrence Handle1614053 Occurrence Handle1:STN:280:By2A3cbntlM%3D

    PubMed  CAS  Google Scholar 

  6. C Ronco G Orlandini A Brendolan A Lupi G La Greca (1998) ArticleTitleEnhancement of convective transport by internal filtration in a modified experimental hemodialyzer: technical note Kidney Int 54 979–85 Occurrence Handle9734626 Occurrence Handle1:STN:280:DyaK1cvgtlKqtw%3D%3D Occurrence Handle10.1046/j.1523-1755.1998.00049.x

    Article  PubMed  CAS  Google Scholar 

  7. C Ronco A Brendolan A Lupi G Metry NW Levin (2000) ArticleTitleEffects of a reduced inner diameter of hollow fibers in hemodialyzers Kidney Int 58 809–17 Occurrence Handle10916106 Occurrence Handle1:CAS:528:DC%2BD3cXlvFagsL4%3D Occurrence Handle10.1046/j.1523-1755.2000.00230.x

    Article  PubMed  CAS  Google Scholar 

  8. C Ronco A Brendolan M Scabardi F Ronco H Nakamura (2001) ArticleTitleBlood flow distribution in a polymyxin coated fibrous bed for endotoxin removal. Effect of a new blood path design Int J Artif Organs 24 167–72 Occurrence Handle11314812 Occurrence Handle1:STN:280:DC%2BD3M3itVyjtQ%3D%3D

    PubMed  CAS  Google Scholar 

  9. R Klingel P Ahrenholz A Schwarting A Rockel (2002) ArticleTitleEnhanced functional performance characteristics of a new polysulfone membrane for high-flux hemodialysis Blood Purif 20 325–33 Occurrence Handle12169840 Occurrence Handle1:CAS:528:DC%2BD38XlvFOitbw%3D Occurrence Handle10.1159/000063099

    Article  PubMed  CAS  Google Scholar 

  10. G Lonnemann L Sereni HD Lemke C Tetta (2001) ArticleTitlePyrogen retention by highly permeable synthetic membranes during in vitro dialysis Artif Organs 25 951–60 Occurrence Handle11843762 Occurrence Handle1:CAS:528:DC%2BD38XnsFahsQ%3D%3D Occurrence Handle10.1046/j.1525-1594.2001.06832.x

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

    Ayumu Nakashima & Shigehiro Doi

  2. Department of Internal Medicine, Sanyo Hospital, 2-8-2 Nogami-cho, Fukuyama, 720-0815, Japan

    Satoshi Ogata

  3. Department of Dialysis, Hakuai Hospital, Kure, Japan

    Michihiro Yamahira, Satoe Naraki & Norihisa Takasugi

  4. Department of Radiology, Kure City Medical Association Hospital, Kure, Japan

    Toshifumi Ohmoto

  5. Section of Nephrology, Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan

    Takafumi Ito

  6. Department of Advanced Nephrology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

    Takao Masaki & Noriaki Yorioka

Authors
  1. Ayumu Nakashima
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Satoshi Ogata
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shigehiro Doi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michihiro Yamahira
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Satoe Naraki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Norihisa Takasugi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Toshifumi Ohmoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Takafumi Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Takao Masaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Noriaki Yorioka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Satoshi Ogata.

About this article

Cite this article

Nakashima, A., Ogata, S., Doi, S. et al. Performance of polysulfone membrane dialyzers and dialysate flow pattern. Clin Exp Nephrol 10, 210–215 (2006). https://doi.org/10.1007/s10157-006-0431-x

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10157-006-0431-x

Key words

Search

Navigation