Abstract
We report a patient with β2 microglobulin amyloidosis (β2M) in whom cystic tumors were seen in the bilateral axillary region. The patient was a 68-year-old woman who had been on hemodialysis for more than 20 years because of IgA nephropathy. Computed tomography-guided biopsy was performed to confirm the diagnosis. Congo red staining, β2M immunohistochemistry, and electron microscopy examination of the biopsied sample showed extended β2M deposits in the cystic tumor. β2M-related amyloidosis in patients with long-term dialysis commonly presents as osteoarticular disease, although a soft-tissue pseudotumor, known as amyloidoma, has been reported. This is the first report in the English-language literature of amyloidosis presenting as bilateral axillary cystic tumors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
TB Drücke (1998) ArticleTitleDialysis-related amyloidosis Nephrol Dial Transplant 13 IssueIDSuppl 1 58s–64s Occurrence Handle10.1093/ndt/13.suppl_1.58
TB Drücke (1999) ArticleTitleExtraskeletal problems and amyloid Kidney Int 56 IssueIDSuppl 739 89s–93s Occurrence Handle10.1046/j.1523-1755.1999.07315.x
K Ohashi (2001) ArticleTitlePathogenesis of β2-microglobulin amyloidosis Pathol Int 51 1–10 Occurrence Handle11148456 Occurrence Handle1:CAS:528:DC%2BD3MXhvFKntLw%3D Occurrence Handle10.1046/j.1440-1827.2001.01156.x
J Floege Ketteler M. β2 (2001) ArticleTitleMicroglobulin-derived amyloidsis: an update Kidney Int 59 IssueIDSuppl 78 164–71 Occurrence Handle10.1046/j.1523-1755.2001.07823.x
T Miyata K Maeda (1995) ArticleTitlePathogenesis of dialysis-related amyloidosis Curr Opin Nephrol Hypertens 4 493–7 Occurrence Handle8591057 Occurrence Handle1:STN:280:BymC28zmvVQ%3D
JM Thealer AEG Raine AJ Rainey A Heryet A Clark DO Oliver (1987) ArticleTitleSystemic amyloidosis of β2 microglobulin type: a complication of long term haemodialysis J Clin Pathol 40 1247–51
H Ogawa A Saito N Hirabayashi K Hara (1987) ArticleTitleAmyloid deposition in systemic organs in long-term hemodialysis patients Clin Nephrol 28 199–204 Occurrence Handle3319310 Occurrence Handle1:STN:280:BieD1c7htFM%3D
AE Lurz U Scheider G Ehlerding H Frenzel KM Koch K Kuehn (1995) ArticleTitleRight ventricular cardiac failure and pulmonary hypertension in long-term dialysis patients – unusual presentation of visceral beta 2-amyloidosis Nephrol Dial Transplant 10 555–8
LH Noel J Zingraff T Bardin et al. (1977) ArticleTitleTissue distribution of dialysis amyloidosis Clin Nephrol 27 175–8
H Araki H Muramoto K Oda I Koni H Mabuchi Y Mizukami A Nonomura (1996) ArticleTitleSevere gastrointestinal complications of dialysis-related amyloidosis in two patients on long-term hemoidialysis Am J Nephrol 16 149–53 Occurrence Handle8919232 Occurrence Handle1:STN:280:ByiD2sfjtVw%3D Occurrence Handle10.1159/000168987
A Sidoni PF Alberti S Bravi E Bucciarelli (1998) ArticleTitleAmyloid tumors in the soft tissues of the legs. Case report and review of the literature Virchows Arch 432 563–6 Occurrence Handle9672199 Occurrence Handle1:STN:280:DyaK1czjsF2hsg%3D%3D Occurrence Handle10.1007/s004280050206
L-H Noel J Zingraff T Bardin C Atienza D Kuntz T Drüecke (1987) ArticleTitleTissue distribution of dialysis amyloidosis Clin Nephrol 27 175–8 Occurrence Handle3555909 Occurrence Handle1:STN:280:BiiB3MnmtFM%3D
R Gal A Korzets A Schartz L Rath-Wolfson U Gafter (1994) ArticleTitleSystemic distribution of β2-microglobulin-derived amyloidosis in patients who undergo long-term hemodialysis Arch Pathol Lab Med 118 718–21 Occurrence Handle8024407 Occurrence Handle1:STN:280:ByuB1Mnit1Y%3D
W Resse A Hopkovitz Lifschitz MD. β2 (1988) ArticleTitleMicroglobulin and associated amyloidosis presenting as popliteal tumor Am J Kidney Dis 12 323–5
CW Hsu MS Wu ML Leu (2001) ArticleTitleDialysis-related cervical amyloidoma presenting with quadriplegia Ren Fail 23 135–8 Occurrence Handle11256523 Occurrence Handle1:STN:280:DC%2BD3Mzptl2ksA%3D%3D Occurrence Handle10.1081/JDI-100001293
Y Aoki K Kaneda N Miyagi M Itoh H Ohmoto (2000) ArticleTitlePopliteal amyloidoma presenting with leg ischemia in a chronic dialysis patient Skeletal Radiol 29 717–20 Occurrence Handle11271554 Occurrence Handle1:STN:280:DC%2BD3M7ntFWhsQ%3D%3D Occurrence Handle10.1007/s002560000282
T Dantoine R Castro M Leblanc JY Bosc F Vaussenat C Bouloux et al. (1997) ArticleTitlePopliteal cysts form advanced amyloidosis in long-term haemofiltration/haemodiafiltration Nephrol Dial Transplant 12 1512–5 Occurrence Handle9249802 Occurrence Handle1:STN:280:ByiA1MzivVE%3D Occurrence Handle10.1093/ndt/12.7.1512
NA Athanasou AJ Chalin DO Oliver (1990) ArticleTitleSubcutaneous deposition of microglobulin amyloid in a long-term haemodialysis patient Nephrol Dial Transplant 5 878–81 Occurrence Handle2128384 Occurrence Handle1:STN:280:By6B3cvitFI%3D
N Homma F Gejyo M Isemura M Arakawa (1989) ArticleTitleCollagen-binding affinity of β2-microglobulin, a preprotein of hemodialysis associated amyloidosis Nephron 53 37–40 Occurrence Handle2674742 Occurrence Handle1:CAS:528:DyaL1MXks1eqsrk%3D Occurrence Handle10.1159/000185699
M Jadoul J Malghem B Van de Berg et al. (1993) ArticleTitleUltrasonographic detection of thickened joint capsules and tendons as marker of dialysis-related amyloidosis: a longitudinal and cross-sectional study Nephrol Dial Transplant 8 1104–9 Occurrence Handle8272224 Occurrence Handle1:STN:280:ByuD1MjltlI%3D
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Ogata, H., Koiwa, F., Takahashi, J. et al. Cystic β2-microglobulin amyloidoma in a patient on long-term hemodialysis. Clin Exp Nephrol 10, 159–161 (2006). https://doi.org/10.1007/s10157-006-0409-8
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10157-006-0409-8