Skip to main content

Advertisement

SpringerLink
Log in

Cimetidine-induced tubulointerstitial nephritis with both MPO-ANCA and PR3-ANCA

  • CASE REPORT
  • Published:
Clinical and Experimental Nephrology Aims and scope Submit manuscript

Abstract

We describe a 75-year-old man with tubulointerstitial nephritis (TIN) with myeloperoxidase (MPO)-antineutrophil antibody (ANCA) and proteinase-3 (PR3)-ANCA. He had a slight fever and eruption with itching after taking cimetidine (prescribed after gastrectomy for gastric cancer) and he was admitted to a nearby hospital. There, he showed proteinuria, serum creatinine (sCr) of 2.9 mg/dl, and creatinine clearance (Ccr) of 44 ml/min per 1.73 m2. His MPO-ANCA titer was 267 EU, and PR3-ANCA titer was 112 EU. Abnormal concentrations in bilateral kidneys were found by gallium scintigraphy. For these reasons, he was transferred to our hospital. Percutaneous renal biopsy was performed after admission. Severe tubular atrophy, mild interstitial fibrosis, and severe mononuclear cell infiltration of the interstitium were noted. Drug-induced renal impairment was suspected, and cimetidine administration was withdrawn. Lymphocyte stimulation tests (DLSTs) were performed. The cimetidine titer was positive, at 2,537 cpm. After the withdrawal of cimetidine, the PR3-ANCA titer was reduced gradually, and, next, the MPO-ANCA titer was also reduced. The sCr level was reduced to 1.2 mg/dl. In summary, we report herein the first case of cimetidine-induced TIN associated with both MPO-ANCA and PR3-ANCA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S Feriozzi AO Muda V Gomes M Montanaro T Faraggiana E Ancarani (2000) ArticleTitleCephotaxime-associated allergic interstitial nephritis and MPO-ANCA positive vasculitis Ren Fail 22 245–51 Occurrence Handle1:STN:280:DC%2BD3c3mtV2itg%3D%3D Occurrence Handle10.1081/JDI-100100869 Occurrence Handle10803769

    Article  CAS  PubMed  Google Scholar 

  2. N Sakai T Wada M Shimizu C Sagawa K Furuichi K Kobayashi et al. (1999) ArticleTitleTubulointerstitial nephritis with anti-neutrophil cytoplasmic antibody following indomethacin treatment Nephrol Dial Transplant 14 2774 Occurrence Handle1:STN:280:DC%2BD3c%2Fgs1Wntg%3D%3D Occurrence Handle10.1093/ndt/14.11.2774 Occurrence Handle10534532

    Article  CAS  PubMed  Google Scholar 

  3. S Singer RG Parry HA Deodbar JN Barnes (1994) ArticleTitleAcute intersitial nephritis, omeprazole and antineutrophil cytoplasmic antibodies Clin Nephrol 42 280 Occurrence Handle1:STN:280:DyaK2M7js1GmsA%3D%3D Occurrence Handle7834928

    CAS  PubMed  Google Scholar 

  4. G Almroth S Enestrom J Hed I Samuelsson P Sjostrom (1992) ArticleTitleAutoantibodies to leucocyte antigens in hydralazine-associated nephritis J Intern Med 231 37–42 Occurrence Handle1:STN:280:DyaK387itFOqsA%3D%3D Occurrence Handle10.1111/j.1365-2796.1992.tb00496.x Occurrence Handle1310098

    Article  CAS  PubMed  Google Scholar 

  5. DJ Shih SM Korbet JJ Rydel MM Schwartz (1995) ArticleTitleRenal vasculitis associated with ciprofloxacin Am J Kidney Dis 26 516–9 Occurrence Handle1:STN:280:DyaK2MzntlGjug%3D%3D Occurrence Handle10.1016/0272-6386(95)90500-6 Occurrence Handle7645562

    Article  CAS  PubMed  Google Scholar 

  6. RG Parry P Gordon JC Mason JE Marley (1996) ArticleTitlePhenytoin-associated vasculitis and ANCA positivity: a case report Nephrol Dial Transplant 11 357–9 Occurrence Handle1:STN:280:DyaK28zisFWqug%3D%3D Occurrence Handle10.1093/oxfordjournals.ndt.a027268 Occurrence Handle8671794

    Article  CAS  PubMed  Google Scholar 

  7. T Kitahara K Hiromura A Maezawa K Ono N Nakahara S Yano et al. (1997) ArticleTitleCase of propylthiouracil-induced vasculitis associated with anti-neutrophil cytoplasmic antibody (ANCA); review of literature Clin Nephrol 47 336–40 Occurrence Handle1:STN:280:DyaK2szisFahuw%3D%3D Occurrence Handle9181282

    CAS  PubMed  Google Scholar 

  8. T Kitahara K Hiromura M Sugawara J Hirato S Sato K Ueki et al. (2000) ArticleTitleA case of cimetidine-induced acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody Am J Kidney Dis 33 7E

    Google Scholar 

  9. KM Dolman RO Gans TJ Vervaat G Zevenbergen D Maingay RE Nikkels et al. (1993) ArticleTitleVasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy Lancet 342 651–2 Occurrence Handle1:STN:280:DyaK3szmvVaqtQ%3D%3D Occurrence Handle10.1016/0140-6736(93)91761-A Occurrence Handle8103148

    Article  CAS  PubMed  Google Scholar 

  10. CJ Kelly EG Neilson (2000) Tubulointerstitial diseases BM Brenner (Eds) The kidney Saunders Philadelphia 1517–21

    Google Scholar 

  11. CL Shuler WM Bennett (2001) Nephropathies due to drugs, chemicals, or physical agents SG Massry Glassock (Eds) Textbook of nephrology Lippincott Williams & Wilkins Philadelphia 912–7

    Google Scholar 

  12. MM Maldonado (1993) Nonrenal neoplasm and the kidney RW Schrier (Eds) Diseases of the kidney Little Brown Boston 2265–85

    Google Scholar 

  13. M Waki E Ishimura H Morii S Sakai S Saitoh T Kobayashi et al. (1997) ArticleTitleA case of membranous glomerulonephritis associated with gastric cancer Osaka City Med J 43 95–105 Occurrence Handle1:STN:280:DyaK1c%2Fgtl2qug%3D%3D Occurrence Handle9343999

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan

    Hideki Ueda, Eiji Ishimura, Takao Tsuchida, Naoki Matsumoto & Syuichi Jono

  2. Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan

    Takayuki Yunoki, Yasuo Imanishi, Masaaki Inaba & Yoshiki Nishizawa

  3. Department of Internal Medicine, Shimada Hospital, 100-1 Kashiyama, Habikino, Osaka, 583-0875, Japan

    Hideki Ueda

Authors
  1. Hideki Ueda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eiji Ishimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takayuki Yunoki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takao Tsuchida
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Naoki Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Syuichi Jono
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yasuo Imanishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Masaaki Inaba
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yoshiki Nishizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hideki Ueda.

About this article

Cite this article

Ueda, H., Ishimura, E., Yunoki, T. et al. Cimetidine-induced tubulointerstitial nephritis with both MPO-ANCA and PR3-ANCA. Clin Exp Nephrol 9, 332–334 (2005). https://doi.org/10.1007/s10157-005-0382-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10157-005-0382-7

Key words

Search

Navigation