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Extensive pancreatic necrosis in microscopic polyangiitis

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Abstract

We encountered an 84-year-old woman with microscopic polyangiitis who was found to have pancreatitis on autopsy. The patient was admitted to Yamanashi University Hospital because of fever and progressive renal failure. She was diagnosed with anti-myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA)-related microscopic polyangiitis (MPA) and was treated successfully with prednisolone pulse therapy. Two months later, she was found unconscious at home and was transferred to hospital, where she died of cardiac arrest after 6 days. Autopsy revealed systemic vasculitis with fibrinoid necrosis (with the most severe form found in the pancreas), interstitial pneumonia, and crescentic glomerulonephritis. A review of the literature revealed that pancreatic involvement in vasculitis, although rare, is one of the complications of MPA; however, the present study is the first report to focus on the pancreatic involvement of MPA. We recommend that nephrologists consider the possibility of pancreatic involvement in this disease.

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Authors and Affiliations

  1. Third Department of Internal Medicine, University of Yamanashi, 1110 Tamaho, Nakakoma, Yamanashi, 409-3898, Japan

    Kazutaka Haraguchi, Kazuaki Gunji, Yuko Ito, Nobuhiko Yokomori, Akio Kawaguchi, Masayuki Ohomori, Hironobu Inoue, Hiroki Shimura, Tsukasa Saito & Tetsuro Kobayashi

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  1. Kazutaka Haraguchi
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  2. Kazuaki Gunji
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  3. Yuko Ito
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  4. Nobuhiko Yokomori
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Correspondence to Kazutaka Haraguchi.

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Haraguchi, K., Gunji, K., Ito, Y. et al. Extensive pancreatic necrosis in microscopic polyangiitis. Clin Exp Nephrol 9, 326–331 (2005). https://doi.org/10.1007/s10157-005-0378-3

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