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Comparison of in-vitro activities of SCH27899 and other antibiotics against Mycoplasma pneumoniae

Abstract

We examined the in-vitro activities of various antibiotics against 25 strains of Mycoplasma pneumoniae (22 clinical isolates and 3 standard strains). In the 22 clinical isolates, the 90% minimum inhibitory concentrations (MIC 90) of SCH27899, ofloxacin, levofloxacin, ciprofloxacin, erythromycin, clarithromycin, roxithromycin, clindamycin, and minocycline were 16, 2, 2, 4, 0.0039, 0.0039, 0.016, 2, and 4 μg/ml, respectively. The minimum bactericidal concentrations (MBC 90) of SCH27899, ofloxacin, levofloxacin, ciprofloxacin, erythromycin, clarithromycin, roxithromycin, clindamycin, and minocycline were 64, 4, 2, 8, 0.0625, 0.0625, 0.125, 8, and 64 μg/ml, respectively. The low sensitivity of M. pneumoniae to SCH27899 may be a result of the impermeability of the bacteria to this molecule. The results of this study suggest that SCH27899 would not be a suitable antimicrobial agent to use in the alternative chemotherapy of M. pneumoniae infection.

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Received: August 17, 2000 / Accepted: January 22, 2001

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Ikejima, H., Yamamoto, H., Ishida, K. et al. Comparison of in-vitro activities of SCH27899 and other antibiotics against Mycoplasma pneumoniae . J Infect Chemother 7, 121–123 (2001). https://doi.org/10.1007/s101560100020

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  • DOI: https://doi.org/10.1007/s101560100020

  • Key wordsMycoplasma pneumoniae
  • SCH27899
  • Everninomicin