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Seroprevalence of Chlamydophila pneumoniae in HIV-infected children in Vietnam


A total of 89 blood samples collected from HIV-infected infants and children from provinces of southern Vietnam who were hospitalized at Children’s Hospital 1, Ho Chi Minh City, during the 1-year period from October 2004 to September 2005 were submitted to serological screening for IgG, IgA, and IgM antibodies against Chlamydophila pneumoniae (C. pneumoniae). The presence of this microorganism was also evaluated by PCR. The results showed that 64 % of the samples were positive for anti-C. pneumoniae IgG, 31.5 % were positive for IgA, and 3.4 % were positive for IgM. The highest prevalences of IgG and IgA positivity, 75 % and 66.7 %, respectively, were noted in the 1- to 2-year-old age group. However, all the samples were negative for C. pneumoniae by PCR. The study revealed a high seroprevalence of C. pneumoniae in Vietnamese infants and children with HIV/AIDS.

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  1. Grayston JT. Chlamydia pneumoniae, strain TWAR pneumonia. Annu Rev Med. 1992;43:317–23.

    PubMed  Article  CAS  Google Scholar 

  2. Montes M, Cilla G, Alcorta M, Perez-Trallero E. High prevalence of Chlamydia pneumoniae infection in children and young adults in Spain. Pediatr Infect Dis J. 1992;11:972–3.

    PubMed  Article  CAS  Google Scholar 

  3. Ben-Yaakov M, Lazarovich Z, Beer S, Levin A, Shoham I, Boldur I. Prevalence of Chlamydia pneumoniae antibodies in patients with acute respiratory infections in Israel. J Clin Pathol. 1994;47:232–5.

    PubMed  Article  CAS  Google Scholar 

  4. Gaydos CA, Roblin PM, Hammerschlag MR, Hyman CL, Eiden JJ, Schachter J, et al. Quinn TC. Diagnostic utility of PCR-enzyme immunoassay, culture, and serology for detection of Chlamydia pneumoniae in symptomatic and asymptomatic patients. J Clin Microbiol. 1994;32:903–5.

    PubMed  CAS  Google Scholar 

  5. Hyman CL, Roblin PM, Gaydos CA, Quinn TC, Schachter J, Hammerschlag MR. Prevalence of asymptomatic nasopharyngeal carriage of Chlamydia pneumoniae in subjectively healthy adults: assessment by polymerase chain reaction-enzyme immunoassay and culture. Clin Infect Dis. 1995;20:1174–8.

    PubMed  Article  CAS  Google Scholar 

  6. Koh WP, Taylor MB, Hughes K, Chew SK, Fong CW, Phoon MC, et al. Seroprevalence of IgG antibodies against Chlamydia pneumoniae in Chinese, Malays and Asian Indians in Singapore. Int J Epidemiol. 2002;31:1001–7.

    PubMed  Article  Google Scholar 

  7. Miyashita N, Fukano H, Yoshida K, Niki Y, Matsushima T. Seroepidemiology of Chlamydia pneumoniae in Japan between 1991 and 2000. J Clin Pathol. 2002;55:115–7.

    PubMed  Article  CAS  Google Scholar 

  8. Lin TM, Kuo CC, Chen WJ, Lin FJ, Eng HL. Seroprevalence of Chlamydia pneumoniae infection in Taiwan. J Infect. 2004;48:91–5.

    PubMed  Article  CAS  Google Scholar 

  9. Cosentini R, Esposito S, Blasi F, Clerici Schoeller M, Pinzani R, Tarsia P, et al. Incidence of Chlamydia pneumoniae infection in vertically HIV-1 infected children. Eur J Clin Microbiol Infect Dis. 1998;17:720–3.

    PubMed  Article  CAS  Google Scholar 

  10. Plebani A, Schoeller MC, Blasi F, Cosentini R. Preliminary data on Chlamydia pneumoniae seroprevalence in HIV-1 infected children. Ann N Y Acad Sci. 1993;693:286–7.

    PubMed  Article  CAS  Google Scholar 

  11. Monno R, Leone E, Maggi P, Buccoliero G, Valenza MA, Angarano G. Chlamydia pneumoniae: a new opportunistic infectious agent in AIDS? Clin Microbiol Infect. 1997;3:187–91.

    PubMed  Article  Google Scholar 

  12. Trinh QD, Pham NT, Lam BQ, Le TP, Truong KH, Le TQ, et al. Subtyping and env C2/V3 sequence analysis of HIV-1 isolated from HIV-infected children hospitalized in Children Hospital 1, Vietnam during 2004–2005. J Trop Pediatr. 2009;55:399–401.

    PubMed  Article  Google Scholar 

  13. Tong CY, Sillis M. Detection of Chlamydia pneumoniae and Chlamydia psittaci in sputum samples by PCR. J Clin Pathol. 1993;46:313–7.

    PubMed  Article  CAS  Google Scholar 

  14. Iijima Y, Miyashita N, Kishimoto T, Kanamoto Y, Soejima R, Matsumoto A. Characterization of Chlamydia pneumoniae species-specific proteins immunodominant in humans. J Clin Microbiol. 1994;32:583–8.

    PubMed  CAS  Google Scholar 

  15. Tositti G, Rassu M, Fabris P, Giordani M, Cazzavillan S, Reatto P, et al. Chlamydia pneumoniae infection in HIV-positive patients: prevalence and relationship with lipid profile. HIV Med. 2005;6:27–32.

    PubMed  Article  CAS  Google Scholar 

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This study was supported by a Grant-in-Aid for Scientific Research under the JSPS (Japan Society for the Promotion of Science) Postdoctoral Fellowships and by Grants-in-Aid from the Japanese Ministries of Education and Sciences and of Heath, Labor and Welfare. The authors thank Dr. Shuji Ando (National Institute of Infectious Diseases, Japan) for kindly providing the Chlamydophila pneumoniae strain KKpn-1.

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Correspondence to Quang Duy Trinh.

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Trinh, Q.D., Pham, N.T.K., Le Nguyen, N.T. et al. Seroprevalence of Chlamydophila pneumoniae in HIV-infected children in Vietnam. J Infect Chemother 19, 538–541 (2013).

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  • Chlamydophila pneumoniae
  • HIV-infected children
  • Seroprevalence
  • Vietnam