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The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy

  • Surveillance
  • Published:
Journal of Infection and Chemotherapy

Abstract

This study was conducted by the Japanese Society of Chemotherapy and is the first nationwide study on bacterial pathogens isolated from patients with urinary tract infections at 28 hospitals throughout Japan between January 2008 and June 2008. A total of 688 bacterial strains were isolated from adult patients with urinary tract infections. The strains investigated in this study are as follows: Enterococcus faecalis (n = 140), Escherichia coli (n = 255), Klebsiella pneumoniae (n = 93), Proteus mirabilis (n = 42), Serratia marcescens (n = 44), and Pseudomonas aeruginosa (n = 114). The minimum inhibitory concentrations of 39 antibacterial agents used for these strains were determined according to the Clinical and Laboratory Standards Institute (CLSI) manual. All Enterococcus faecalis strains were susceptible to ampicillin and vancomycin. Although a majority of the E. faecalis strains were susceptible to linezolid, 11 strains (7.8%) were found to be intermediately resistant. The proportions of fluoroquinolone-resistant Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and S. marcescens strains were 35.7%, 29.3%, 18.3%, and 15.2%, respectively. The proportions of E. coli, P. mirabilis, K. pneumoniae, and S. marcescens strains producing extended-spectrum β-lactamase were 5.1%, 11.9%, 0%, and 0%, respectively. The proportions of Pseudomonas aeruginosa strains resistant to carbapenems, aminoglycosides, and fluoroquinolones were 9.2%, 4.4%, and 34.8%, respectively, and among them, 2 strains (1.8%) were found to be multidrug resistant. These data present important information for the proper treatment of urinary tract infections and will serve as a useful reference for periodic surveillance studies in the future.

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Acknowledgments

This study was supported by grants from the following pharmaceutical companies (listed in alphabetical order): Abbott Japan Co., Ltd.; Astellas Pharma Inc.; Banyu Pharmaceutical Co., Ltd.; Bayer Yakuhin, Ltd.; Chugai Pharmaceutical Co., Ltd.; Daiichi Sankyo Co., Ltd.; Dainippon Sumitomo Pharma Co., Ltd.; GlaxoSmithKline K. K.; Kyorin Pharmaceutical Co., Ltd.; Maruho Co., Ltd.; Meiji Seika Kaisha, Ltd.; Pfizer Japan Inc.; Sanofi-Aventis K.K.; Shionogi & Co., Ltd.; Taiho Pharmaceutical Co., Ltd.; Taisho Pharmaceutical Co., Ltd.; Takeda Pharmaceutical Co., Ltd.; and Toyama Chemical Co., Ltd. We are grateful to T. Nakae and C. Yanagisawa of Kitasato University (Tokyo, Japan) for their encouragement, and we thank Y. Suzuki, H. Endo, and Y. Yamaguchi for their technical assistance.

Author information

Authors and Affiliations

  1. Japanese Society of Chemotherapy (JSC), Nichinai Kaikan B1, 3-28-8 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Kiyohito Ishikawa, Tetsuro Matsumoto, Mitsuru Yasuda, Shinya Uehara, Tetsuro Muratani, Morimasa Yagisawa, Junko Sato, Yoshihito Niki, Kyoichi Totsuka, Keisuke Sunakawa, Rikizo Hattori, Michinori Terada, Tsuneo Kozuki, Akinori Maruo, Kohei Morita, Kazuhiko Ogasawara, Yoshisaburo Takahashi & Kenji Matsuda

  2. The Kitasato University, Tokyo, Japan

    Hideaki Hanaki

  3. Hokkaido Social Insurance Hospital, Hokkaido, Japan

    Takaoki Hirose

  4. Muroran City General Hospital, Hokkaido, Japan

    Noriomi Miyao & Tasuku Hayashi

  5. National Hospital Organization Hakodate National Hospital, Hokkaido, Japan

    Koh Takeyama

  6. Jikei University Affiliated Aoto Hospital, Tokyo, Japan

    Hiroshi Kiyota, Masayuki Tomita, Hisashi Yusu, Haruhisa Koide & Shoji Kimura

  7. Fujita Health University, Aichi, Japan

    Kiyohito Ishikawa

  8. Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan

    Masanori Yanaoka & Hajime Sato

  9. Nagoya Ekisaikai Hospital, Aichi, Japan

    Toru Ito

  10. Gifu University Hospital, Gifu, Japan

    Mitsuru Yasuda & Takashi Deguchi

  11. Ogaki Municipal Hospital, Gifu, Japan

    Yoshinori Fujimoto, Hisao Komeda & Yuko Asano

  12. Gifu Prefectural General Medical Center, Gifu, Japan

    Yoshito Takahashi

  13. Kizawa Memorial Hospital, Gifu, Japan

    Satoshi Ishihara

  14. Kobe University Hospital, Hyogo, Japan

    Soichi Arakawa, Yuzo Nakano, Kazushi Tanaka & Masato Fujisawa

  15. Japanese Red Cross Kobe Hospital, Hyogo, Japan

    Takashi Matsui

  16. Nippon Steel Hirohata Hospital, Hyogo, Japan

    Akira Fujii

  17. Hyogo College of Medicine, Hyogo, Japan

    Shingo Yamamoto, Michio Nojima, Yoshihide Higuchi & Yasuo Ueda

  18. Nishi Kobe Medical Center, Hyogo, Japan

    Sojun Kanamaru

  19. Araki Urological Clinic, Okayama, Japan

    Koichi Monden

  20. National Hospital Organization Okayama Medical Center, Okayama, Japan

    Tomoyasu Tsushima & Yuko Seno

  21. Okayama Citizens’ Hospital, Okayama, Japan

    Masaya Tsugawa

  22. Japanese Red Cross Okayama Hospital, Okayama, Japan

    Tadasu Takenaka

  23. University of Occupational and Environmental Health, Fukuoka, Japan

    Tetsuro Matsumoto, Ryoichi Hamasuna, Naohiro Fujimoto & Takehiko Sho

  24. Fukuoka Shin Mizumaki Hospital, Fukuoka, Japan

    Koichi Takahashi

  25. Munakata Suikokai General Hospital, Fukuoka, Japan

    Hisato Inatomi

  26. Ikei Hospital, Miyazaki, Japan

    Naoya Takahashi & Yoshihiko Ikei

  27. Kagoshima University Hospital, Kagoshima, Japan

    Hiroshi Hayami, Takashi Yamane & Masayuki Nakagawa

  28. National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan

    Satoru Kariya

  29. Tarumizu Chuo Hospital, Kagoshima, Japan

    Takashi Arima

Authors
  1. Kiyohito Ishikawa
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  2. Tetsuro Matsumoto
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  3. Mitsuru Yasuda
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  4. Shinya Uehara
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  6. Morimasa Yagisawa
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  7. Junko Sato
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  8. Yoshihito Niki
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  10. Keisuke Sunakawa
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  13. Michinori Terada
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  18. Yoshisaburo Takahashi
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  19. Kenji Matsuda
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  49. Koichi Monden
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  56. Takehiko Sho
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  58. Hisato Inatomi
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  65. Takashi Arima
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Corresponding author

Correspondence to Kiyohito Ishikawa.

Additional information

K. Ishikawa, T. Matsumoto, M. Yasuda, S. Uehara, T. Muratani, M. Yagisawa, J. Sato, Y. Niki, K. Totsuka, K. Sunakawa, R. Hattori, M. Terada, T. Kozuki, A. Maruo, K. Morita, K. Ogasawara, Y. Takahashi and K. Matsuda are the members of Japanese Society of Chemotherapy (JSC) Surveillance Committee, Japan.

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Ishikawa, K., Matsumoto, T., Yasuda, M. et al. The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy. J Infect Chemother 17, 126–138 (2011). https://doi.org/10.1007/s10156-010-0174-1

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  • DOI: https://doi.org/10.1007/s10156-010-0174-1

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