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Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients more than 18 years of age

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Journal of Infection and Chemotherapy

Abstract

A macrolide-resistant Mycoplasma pneumoniae strain was isolated from two patients with community-acquired pneumonia. The pneumonia severity score of both patients was mild, and rapid clinical improvement was seen after administration of fluoroquinolone. Clinical features of macrolide-resistant M. pneumoniae pneumonia were identical to those of macrolide-sensitive M. pneumoniae pneumonia. An A-to-G transition at position 2063 and 2064, respectively, in domain V of the 23S rRNA gene was identified. The minimum inhibitory concentration of erythromycin of these isolates was greatly elevated. In Japan, macrolide-resistant M. pneumoniae infections are common in pediatric patients but not in adults. However, physicians should pay attention to macrolide-resistant M. pneumoniae not only in children but also in adults.

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Acknowledgments

This work was supported by MEXT KAKENHI (19591190 and 21591304) and Project Research Grants from Kawasaki Medical School (13-401, 14-402, 15-405A, 16-405M, 17-402M, 18-401, 19-402M, 20-4030).

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Authors and Affiliations

  1. Department of Respiratory Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan

    Naoyuki Miyashita & Mikio Oka

  2. Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Japan

    Takaya Maruyama, Tetsu Kobayashi, Hiroyasu Kobayashi & Osamu Taguchi

  3. Department of Pediatrics, Kawasaki Medical School, Kurashiki, Japan

    Yasuhiro Kawai, Tetsuya Yamaguchi & Kazunobu Ouchi

Authors
  1. Naoyuki Miyashita
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  2. Takaya Maruyama
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  3. Tetsu Kobayashi
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  4. Hiroyasu Kobayashi
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  5. Osamu Taguchi
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  6. Yasuhiro Kawai
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  7. Tetsuya Yamaguchi
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  8. Kazunobu Ouchi
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  9. Mikio Oka
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Corresponding author

Correspondence to Naoyuki Miyashita.

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Miyashita, N., Maruyama, T., Kobayashi, T. et al. Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients more than 18 years of age. J Infect Chemother 17, 114–118 (2011). https://doi.org/10.1007/s10156-010-0093-1

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  • DOI: https://doi.org/10.1007/s10156-010-0093-1

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