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Vaccine-associated paralytic poliomyelitis in an infant with perianal abscesses

  • Case Report
  • Published:
Journal of Infection and Chemotherapy

Abstract

We describe a case of vaccine-associated paralytic poliomyelitis (VAPP) in a 7-month-old infant with perianal abscesses. The infant had suffered from perianal abscesses from 3 weeks after birth. The abscesses repeatedly developed and spontaneously drained through the orifice. Twenty-seven days before admission, a live attenuated oral poliovirus vaccine (OPV) was given to the infant for the first time for routine immunization. His body temperature rose to 38°C 19 days after receiving the OPV and fell 4 days later. Flaccid paralysis of the right leg appeared 26 days after receipt of the OPV. A Sabin type 3 poliovirus was isolated from a stool obtained at admission. The DNA sequences of the VP1 region of the isolated virus were more than 99% identical with those of the vaccine strain. Mild muscle atrophy with moderate motor impairment in the right leg persisted at 18 months of age. One VAPP case provoked by a perianal abscess has been reported from the United Kingdom. Database search revealed that one of nine VAPP cases reported during 2003–2008 in Japan had a perianal abscess. Taken together, these reports and our case imply that we should give OPV with caution to infants with a perianal abscess.

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Acknowledgments

We thank Dr. Shigehiro Akachi, Mie prefecture Health and Environment Research Institute, for isolation and identification of the poliovirus.

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Authors and Affiliations

  1. Department of Pediatrics, Yamada Red Cross Hospital, 810 Takabuku, Misono-cho, Ise, 516-0805, Japan

    Masamune Higashigawa, Kayoka Maegawa, Hitoshi Honma, Ayako Yoshino, Kaori Onozato, Yuji Nashida, Takashi Fujiwara & Masakazu Inoue

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  1. Masamune Higashigawa
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  2. Kayoka Maegawa
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  3. Hitoshi Honma
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  4. Ayako Yoshino
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  5. Kaori Onozato
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  7. Takashi Fujiwara
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  8. Masakazu Inoue
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Correspondence to Masamune Higashigawa.

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Higashigawa, M., Maegawa, K., Honma, H. et al. Vaccine-associated paralytic poliomyelitis in an infant with perianal abscesses. J Infect Chemother 16, 356–359 (2010). https://doi.org/10.1007/s10156-010-0065-5

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  • DOI: https://doi.org/10.1007/s10156-010-0065-5

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