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Chronic Helicobacter pylori infection is associated with peripheral arterial disease

Abstract

It is reported that Helicobacter pylori infection is associated with coronary atherosclerosis both epidemiologically and pathogenetically, but no conclusions have yet been reached. Therefore, we investigated the relationship between H. pylori infection and peripheral arterial disease (PAD). Sixty-nine patients with PAD attending Harasanshin General Hospital (Fukuoka, Japan) were compared with 143 controls (age-matched asymptomatic outpatients with hyperlipidemia). H. pylori infection was diagnosed by the detection of IgG antibodies, the 13C-urea breath test, and histological examination. Multiple logistic regression analysis was used to assess the data. The 69 PAD patients and 143 controls were aged from 50 to 92 years. According to the Fontaine classification, 43/69 PAD patients (62.3%) were grade I, 25 (36.2%) were grade II, and 1 (0.14%) was grade III. The prevalence of H. pylori infection was higher in the PAD patients than in the controls (79.7% versus 44.8%; P < 0.01). Stepwise logistic regression analysis revealed that H. pylori infection and hypertension had a significant influence on the occurrence of PAD. Our results suggest that chronic H. pylori infection may be one of the risk factors for PAD.

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References

  1. Mendall MA, Goggin PM, Molineaux N, Levy J, Toosy T, Strachan D, et al. Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J 1994;71:437–439.

    PubMed  Article  CAS  Google Scholar 

  2. Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease: is there a link? Lancet 1997;350:430–436.

    PubMed  Article  CAS  Google Scholar 

  3. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999;340:115–126.

    PubMed  Article  CAS  Google Scholar 

  4. Maeda N, Sawayama Y, Tatsukawa M, Shimizu C, Kashiwagi S, Hayashi J. Chlamydia pneumoniae seropositivity and early carotid atherosclerosis in a suburban Japanese population. Atherosclerosis 2002;164:313–319.

    PubMed  Article  CAS  Google Scholar 

  5. Tatsukawa M, Sawayama Y, Maeda N, Okada K, Furusyo N, Kashiwagi S, et al. Carotid atherosclerosis and cardiovascular risk factors: a comparison of residents of a rural area of Okinawa with residents of a typical suburban area of Fukuoka, Japan. Atherosclerosis 2004;172:337–343.

    Article  CAS  Google Scholar 

  6. Okada K, Maeda N, Tatsukawa M, Shimizu C, Sawayama Y, Hayashi J. The influence of lifestyle modification on carotid artery intima-media thickness in a suburban Japanese population. Atherosclerosis 2004;173:329–337.

    PubMed  Article  CAS  Google Scholar 

  7. Newman AB, Shemanski L, Manolio TA, Cushman M, Mittelmark M, Polak JF, et al. Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 1999;19:538–545.

    PubMed  CAS  Google Scholar 

  8. CAPRIE Steering Committee. A randomized, blinded, trial of clopidogrel versus aspirin in patients at risk of ischemic events (CAPRIE). Lancet 1996;348:329–339.

    Google Scholar 

  9. Sawayama Y, Hamada M, Otaguro Y, Maeda S, Ohnishi H, Taira T, et al. The impact of peripheral arterial disease and acute ischemic stroke. Fukuoka Igaku Zasshi. 2006;97:293–301.

    PubMed  Google Scholar 

  10. Saikku P, Leinonen M, Mattila K, Ekman MR, Nieminen MS, Makela PH, et al. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet 1988;2:983–986.

    PubMed  Article  CAS  Google Scholar 

  11. Sawayama Y, Ariyama I, Hamada M, Otaguro S, Machi T, Taira Y, et al. Association between chronic Helicobacter pylori infection and acute ischemic stroke: Fukuoka Harasanshin Atherosclerosis Trial (FHAT). Atherosclerosis. 2005;178:303–309.

    PubMed  Article  CAS  Google Scholar 

  12. Ito M, Mishima Y. Risk factor, natural history and prognosis of the patients with arteriosclerosis obliterans. Nippon Geka Gakkai Zasshi 1996;97:476–480.

    PubMed  CAS  Google Scholar 

  13. Pius H, Christoph B. Nondisperative infrared spectrometry: a new method for the detection of Helicobacter pylori with the 13C-urea breath test. Clin Infect Dis 1997;25:1003–1005.

    Article  Google Scholar 

  14. Ohara S, Kato M, Asaka M, Toyota T. The UBiT-100 13CO2 infrared analyzer: comparison between infrared spectrometric analysis and mass spectrometric analysis. Helicobacter 1998;3:49–53.

    PubMed  Article  CAS  Google Scholar 

  15. Dixon MF, Gentra RM, Yardley JH, Correa P. Classification and grading of gastritis: the updated Sydney system. Am J Surg Pathol 1996;20:1161–1181.

    PubMed  Article  CAS  Google Scholar 

  16. Yamashina A, Tomiyama H, Takeda H, Tsuda H, Arai T, Hirose R, et al. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002;25:359–364.

    PubMed  Article  Google Scholar 

  17. Fujimoto Y, Furusyo N, Toyoda K, Takeoka H, Sawayama Y, Hayashi J. Intrafamilial transmission of Helicobacter pylori among the population of endemic areas of Japan. Helicobacter 2007;12:170–176.

    PubMed  Article  Google Scholar 

  18. Sawayama Y, Shimizu C, Maeda N, Tatsukawa M, Kinukawa N, Koyanagi S, et al. Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka Atherosclerosis Trial (FAST). J Am Coll Cardiol 2002;20;39:610–616.

    Article  Google Scholar 

  19. Sawayama Y, Tatsukawa M, Okada K, Maeda N, Shimizu C, Kikuchi K, et al. Association of Chlamydia pneumoniae antibody with the cholesterol-lowering effect of statins. Atherosclerosis 2003;171:281–285.

    PubMed  Article  CAS  Google Scholar 

  20. Salomaa V, Niemela M, Miettinen H, Ketonen M, Immonen-Raiha P, Koskinen S, et al. Relationship of socioeconomic status to the incidence and prehospital, 28-day, and 1-year mortality rates of acute coronary events in the FINMONICA myocardial infarction register study. Circulation 2000;101:1913–1918.

    PubMed  CAS  Google Scholar 

  21. Danesh J, Peto R. Risk factors for coronary heart disease and infection with Helicobacter pylori: meta-analysis of 18 studies. BMJ 1998;316:1130–1132.

    PubMed  CAS  Google Scholar 

  22. Maeda S, Kanai F, Ogura K, Yoshida H, Ikenoue T, Takahashi M, et al. High seropositivity of anti-CagA antibody in Helicobacter pylori-infected patients irrelevant to peptic ulcers and normal mucosa in Japan. Dig Dis Sci 1997;42:1841–1847.

    PubMed  Article  CAS  Google Scholar 

  23. Ameriso SF, Fridman EA, Leiguarda RC, Sevlever GE. Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke 2001;32:385–391.

    PubMed  CAS  Google Scholar 

  24. Stone AF, Mendall MA, Kaski JC, Edger TM, Risley P, Poloniecki J, et al. Effect of treatment for Chlamydia pneumoniae and Helicobacter pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes: South Thames Trial of Antibiotics in Myocardial Infarction and Unstable Angina (STAMINA). Circulation 2002;106:1219–1223.

    PubMed  Article  CAS  Google Scholar 

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Correspondence to Yasunori Sawayama.

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Sawayama, Y., Hamada, M., Otaguro, S. et al. Chronic Helicobacter pylori infection is associated with peripheral arterial disease. J Infect Chemother 14, 250–254 (2008). https://doi.org/10.1007/s10156-008-0613-4

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  • DOI: https://doi.org/10.1007/s10156-008-0613-4

Key words

  • Helicobacter pylori
  • Peripheral arterial disease (PAD)
  • Atherosclerosis