Skip to main content
Log in

Recent changes in the trends of seasonal influenza outbreaks in the Nagano Prefectural area of Japan: an oseltamivir effect?

  • NOTE
  • Published:
Journal of Infection and Chemotherapy

Abstract

We carried out a study to assess the pharmacological role of oseltamivir in the regulation of influenza epidemics in Japan, examining data for the years 1998 to 2006 from Nagano Prefecture. Oseltamivir is effective for the treatment of influenza, and its use in Japan has increased in the 3 years from 2003 to 2006. We found that, in the Nagano Prefectural area, the peak in the number of influenza infections showed a deviation to later periods after the 2003 season. and after 2003, it also took a longer time to reach the end of the seasonal epidemics of influenza infections compared with data from 1998 to 2002. To prevent influenza outbreaks having a long duration, we believe that the period of isolation in patients receiving anti-influenza drugs has to be reconsidered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. KG Nicholson FY Aoki ADME Osterhaus S Trottier O Carewicz CH Mercier et al. (2000) ArticleTitleEfficacy and safety of oseltamivir in treatment of acute influenza: a randomized controlled trial Lancet 355 1845–50 Occurrence Handle10866439 Occurrence Handle10.1016/S0140-6736(00)02288-1 Occurrence Handle1:CAS:528:DC%2BD3cXkt1Crsb0%3D

    Article  PubMed  CAS  Google Scholar 

  2. JJ Treanor FG Hayden PS Vrooman R Barbarash R Bettis D Riff et al. (2000) ArticleTitleEfficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial JAMA 283 1016–24 Occurrence Handle10697061 Occurrence Handle10.1001/jama.283.8.1016 Occurrence Handle1:CAS:528:DC%2BD3cXhs1Grsb4%3D

    Article  PubMed  CAS  Google Scholar 

  3. RJ Whitney FG Hayden KS Reisinger N Young R Dutkowski D Ipe et al. (2001) ArticleTitleOral oseltamivir treatment of influenza in children Pediatr Infect Dis J 20 127–33 Occurrence Handle10.1097/00006454-200102000-00002

    Article  Google Scholar 

  4. A Moscona (2005) ArticleTitleNeuraminidase inhibitors for influenza N Engl J Med 353 1363–73 Occurrence Handle16192481 Occurrence Handle10.1056/NEJMra050740 Occurrence Handle1:CAS:528:DC%2BD2MXhtVGmtL3L

    Article  PubMed  CAS  Google Scholar 

  5. Public disclosure report. Pediatric advisory committee executive summary for Tamiflu. Roche Research Report 2005; Nov:1–18

  6. M Sato M Hosoya K Kato H Suzuki (2005) ArticleTitleViral shedding in children with influenza virus infections treated with neuraminidase inhibitors Pediatr Infect Dis J 24 931–2 Occurrence Handle16220098 Occurrence Handle10.1097/01.inf.0000180976.81055.ce

    Article  PubMed  Google Scholar 

  7. MB Rothberg D Fisher B Kelly DN Rose (2005) ArticleTitleManagement of influenza symptoms in healthy children Arch Pediatr Adolesc Med 159 1055–62 Occurrence Handle16275797 Occurrence Handle10.1001/archpedi.159.11.1055

    Article  PubMed  Google Scholar 

  8. MJ Friedman MW Attia (2004) ArticleTitleClinical predictors of influenza in children Arch Pediatr Adolesc Med 158 391–4 Occurrence Handle15066881 Occurrence Handle10.1001/archpedi.158.4.391

    Article  PubMed  Google Scholar 

  9. N Kawai H Ikematsu N Iwaki T Maeda I Satoh N Hirotsu et al. (2006) ArticleTitleA comparison of the effectiveness of oseltamivir for the treatment of influenza A and influenza B: a Japanese multicenter study of the 2003–2004 and 2004–2005 influenza seasons Clin Infect Dis 43 439–44 Occurrence Handle16838232 Occurrence Handle10.1086/505868 Occurrence Handle1:CAS:528:DC%2BD28XovFWgsrs%3D

    Article  PubMed  CAS  Google Scholar 

  10. T Kasai T Togashi T Morishima (2000) ArticleTitleEncephalopathy associated with influenza epidemics Lancet 355 1558–9 Occurrence Handle10801205 Occurrence Handle10.1016/S0140-6736(05)74614-6 Occurrence Handle1:STN:280:DC%2BD3c3lvFWnsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  11. J Kawada H Kimura Y Ito S Hara M Iriyama T Yoshikawa et al. (2003) ArticleTitleSystemic cytokine responses in patients with influenza-associated encephalopathy J Infect Dis 188 690–8 Occurrence Handle12934185 Occurrence Handle10.1086/377101 Occurrence Handle1:CAS:528:DC%2BD3sXnvFyisbY%3D

    Article  PubMed  CAS  Google Scholar 

  12. AL Frank LH Taber CR Wells JM Wells WP Glezen A Paredes (1981) ArticleTitlePatterns of shedding of myxoviruses and paramyxoviruses in children J Infect Dis 144 433–41 Occurrence Handle6273473 Occurrence Handle1:STN:280:Bi2D2snmsFE%3D

    PubMed  CAS  Google Scholar 

  13. K Kano S Sunagawa N Shimura O Arisaka (2007) ArticleTitleDuration of isolation of children with influenza A treated with oseltamivir Eur J Pediatr 166 185–6 Occurrence Handle16906398 Occurrence Handle10.1007/s00431-006-0227-8

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kozo Yasui.

About this article

Cite this article

Yasui, K., Amano, Y., Minami, I. et al. Recent changes in the trends of seasonal influenza outbreaks in the Nagano Prefectural area of Japan: an oseltamivir effect?. J Infect Chemother 13, 429–431 (2007). https://doi.org/10.1007/s10156-007-0554-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10156-007-0554-3

Key words

Navigation