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Outbreak of CTX-M-3-type extended-spectrum β-lactamase-producing Enterobacter cloacae in a pediatric ward


A first resistant strain of Enterobacter cloacae was isolated from a blood specimen in a pediatric patient with immature teratoma-developed sepsis after combination chemotherapy. The strain produced extended-spectrum β-lactamase (ESBL), and the same ESBL-producing strains were detected in urine samples from other patients in the pediatric ward. All strains harbored genes for bla CTX-M-3 by polymerase chain reaction (PCR) and sequencing analysis. Analysis of pulsed-field gel electrophoresis revealed that all strains were the same clonal type. These results suggest that ESBL-producing strains might be transmitted in the ward via contact among patients or medical staff.

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Correspondence to Naohiko Moriguchi.

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Moriguchi, N., Itahashi, Y., Tabata, N. et al. Outbreak of CTX-M-3-type extended-spectrum β-lactamase-producing Enterobacter cloacae in a pediatric ward. J Infect Chemother 13, 263–266 (2007).

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Key words

  • Extended-spectrum β-lactamase (ESBL)
  • CTX-M type
  • Enterobacter cloacae
  • Sepsis
  • Nosocomial infection