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Study of nasopharyngeal bacterial flora. Second report. Variations in nasopharyngeal bacterial flora in children aged 6 years or younger when administered antimicrobial agents. Part 2

  • ORIGINAL ARTICLE
  • Published:
Journal of Infection and Chemotherapy

Abstract

This report focuses on changes in the nasopharyngeal bacterial flora before and after administration of antimicrobial agents in 172 cases of acute upper respiratory infection in patients aged 6 years or younger. The antimicrobial agents administered were amoxicillin (AMPC) (34%), clavulanic acid/amoxicillin compound (11%), cefditren pivoxil (CDTR-PI) (43%), and others (12%). Changes in nasopharyngeal bacterial flora were investigated with reexaminations conducted after 2–5 days (day 2–5 subgroup), 6–10 days (day 6–10 subgroup), and 11 days and thereafter. There was a significant reduction in the Streptococcus pneumoniae detected in the group administered AMPC (AMPC group) in the day 2–5 subgroup and the day 6–10 subgroup. There was also a significant decrease in H. influenzae in the group administered CDTR-PI (CDTR-PI group) in the day 2–5 subgroup. From this it was inferred that for the most part significant changes in infectious nasopharyngeal bacteria occurred in the day 2–5 subgroups. However, a significant improvement in the degree of inflammation, as indicated by leukocyte infiltration images for the AMPC group, was observed in the day 2–5 subgroup, and for the CDTR-PI group in the day 6–10 subgroup. On the other hand, in both the antimicrobial agent groups, S. pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were newly detected at reexamination. Furthermore, a difference in the incidence of these bacteria was observed between the 2 antimicrobial agent groups. It was suggested that such phenomena related to the survival of resistant strains or a recurrence otitis media.

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Author information

Author notes

  1. Masatoshi Konno

    Present address: , 37-10 Sengoku 3-chome, Bunkyo-ku, Tokyo, 112-0011, Japan

Authors and Affiliations

  1. Teikyo University School of Medicine, Tokyo, Japan

    Masatoshi Konno

  2. Nagoya City University Graduate School of Medical Sciences, Medical School, Nagoya, Japan

    Shunkichi Baba

  3. Kyoto University, Graduate School of Medicine, Faculty of Medicine, Kyoto, Japan

    Haruki Mikawa

  4. Nagasaki University School of Medicine, Nagasaki, Japan

    Kohei Hara & Shigeru Kohno

  5. The Jikei School of Medicine, Tokyo, Japan

    Fumio Matsumoto

  6. Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan

    Kimitaka Kaga

  7. Fujita Health University School of Medicine, Nagoya, Japan

    Tadao Nishimura

  8. Tohoku University, Graduate School of Medicine and School of Medicine, Sendai, Japan

    Toshimitsu Kobayashi

  9. Gunma University, Graduate School of Medicine, Takasaki, Japan

    Nobuhiko Furuya & Akihiro Morikawa

  10. The Jikei School of Medicine, Tokyo, Japan

    Hiroshi Moriyama

  11. Graduate School of Medicine, Chiba University, Chiba, Japan

    Yoshitaka Okamoto

  12. Kanazawa University, Graduate School of Medical Science, School of Medicine, Kanazawa, Japan

    Mituru Furukawa & Shoichi Koizumi

  13. Wakayama Medical University, Wakayama, Japan

    Noboru Yamanaka

  14. Kawasaki Medical School, Kurashiki, Japan

    Toshiharu Matsushima

  15. Tokyo Medical and Dental University, Graduate School of Medicine, Tokyo, Japan

    Yasuyuki Yoshizawa

  16. Hokkaido University, Graduate School of Medicine, Sapporo, Japan

    Kunihiko Kobayashi

  17. School of Medicine, Kitasato University, Sagamihara, Japan

    Keisuke Sunakawa & Matsuhisa Inoue

  18. Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Tokyo, Japan

    Kimiko Ubukata

Authors
  1. Masatoshi Konno
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  2. Shunkichi Baba
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  3. Haruki Mikawa
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  4. Kohei Hara
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  5. Fumio Matsumoto
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  6. Kimitaka Kaga
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  7. Tadao Nishimura
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  8. Toshimitsu Kobayashi
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  9. Nobuhiko Furuya
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  10. Hiroshi Moriyama
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  11. Yoshitaka Okamoto
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  12. Mituru Furukawa
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  13. Noboru Yamanaka
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  14. Toshiharu Matsushima
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  15. Yasuyuki Yoshizawa
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  16. Shigeru Kohno
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  17. Kunihiko Kobayashi
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  18. Akihiro Morikawa
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  19. Shoichi Koizumi
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  20. Keisuke Sunakawa
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  21. Matsuhisa Inoue
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  22. Kimiko Ubukata
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Corresponding author

Correspondence to Masatoshi Konno.

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Cite this article

Konno, M., Baba, S., Mikawa, H. et al. Study of nasopharyngeal bacterial flora. Second report. Variations in nasopharyngeal bacterial flora in children aged 6 years or younger when administered antimicrobial agents. Part 2. J Infect Chemother 12, 305–330 (2006). https://doi.org/10.1007/s10156-006-0469-4

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  • DOI: https://doi.org/10.1007/s10156-006-0469-4

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