Skip to main content
SpringerLink
Log in

Multiple doses of cefodizime are necessary for the treatment of Neisseria gonorrhoeae pharyngeal infection

  • ORIGINAL ARTICLE
  • Published:
Journal of Infection and Chemotherapy

Abstract

A single dose of cefodizime (CDZM), ceftriaxone (CTRX), or spectinomycin (SPCM) is recommended for the treatment of gonococcal urethritis or uterine cervicitis in the era of multidrug-resistant Neisseria gonorrhoeae; namely, cefozopran-resistant N. gonorrhoeae (CZRNG). N. gonorrhoeae pharyngeal infection is not so rare in Japan; however, the proper treatment regimen for this infection is not clear. We previously found that a single dose of CDZM completely eradicated multidrug-resistant N. gonorrhoeae in patients with urethritis and uterine cervicitis, so we tried a single 1.0-g dose of CDZM for the treatment of N. gonorrhoeae pharyngeal infection, including infections with CZRNG. The eradication rate of N. gonorrhoeae from the pharynx was 63.0% with a single 1.0-g dose of CDZM, while the rate for CZRNG with the same dose of CDZM was 38.5%. N. gonorrhoeae was completely eradicated from the pharynx when patients received one or two additional doses of CDZM. Therefore, we concluded that two to three doses of CDZM were necessary for the treatment of N. gonorrhoeae pharyngeal infection including infection with CZRNG.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. T Iyoda T Saika A Kanayama M Hasegawa I Kobayashi Y Onoe et al. (2003) ArticleTitleBacteriological and epidemiological study on Nesseria gonorrhoeae isolated from the pharyngeal specimens of male and female patients with gonorrhoea (in Japanese) Kansenshogaku Zasshi 77 103–9 Occurrence Handle12661086

    PubMed  Google Scholar 

  2. KA Workowski WC Levine (2002) ArticleTitleSexually transmitted diseases; treatment guidelines, 2002 MMWR 51 IssueIDRR06 1–80

    Google Scholar 

  3. M Ito M Yasuda S Yokoi S Ito Y Takahashi S Ishihara et al. (2004) ArticleTitleRemarkable increase in central Japan in 2001–2002 of Neisseria gonorrhoeae isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones Antimicrob Agents Chemother 48 3185–7 Occurrence Handle15273147 Occurrence Handle1:CAS:528:DC%2BD2cXmtlKqur4%3D Occurrence Handle10.1128/AAC.48.8.3185-3187.2004

    Article  PubMed  CAS  Google Scholar 

  4. M Tanaka H Nakayama T Notomi S Irie Y Tsunoda A Okadome et al. (2004) ArticleTitleAntimicrobial resistance of Neisseria gonorrhoeae in Japan, 1993–2002: continuous increasing of ciprofloxacin-resistant isolates Int J Antimicrob Agents 24 15–22 Occurrence Handle1:CAS:528:DC%2BD2cXnsFSgurc%3D Occurrence Handle10.1016/j.ijantimicag.2004.02.005

    Article  CAS  Google Scholar 

  5. T Muratani S Akasaka T Kobayashi Y Yamada H Inatomi K Takahashi et al. (2001) ArticleTitleOutbreak of cefozopran (penicillin, oral cephems, and aztreonam)-resistant Nesseria gonorrhoeae in Japan Antimicrob Agents Chemother 45 3603–6 Occurrence Handle11709349 Occurrence Handle1:CAS:528:DC%2BD3MXovVOksLk%3D Occurrence Handle10.1128/AAC.45.12.3603-3606.2001

    Article  PubMed  CAS  Google Scholar 

  6. T Matsumoto T Muratani K Takahashi Y Ando Y Sato M Kurashima et al. (2006) ArticleTitleSingle dose of cefodizime completely eradicated multi-drug resistant strains of Neisseria gonorrhoeae in urethritis and uterine cervicitis J Infect Chemother 12 97–9 Occurrence Handle16648949 Occurrence Handle1:CAS:528:DC%2BD28XktVSgt7o%3D Occurrence Handle10.1007/s10156-006-0431-5

    Article  PubMed  CAS  Google Scholar 

  7. InstitutionalAuthorNameNational Committee for Clinical Laboratory Standards (1999) Performance standards for antimicrobial susceptibility testing, 9th informational supplement M7-A4 (M100-S9) National Committee for Clinical Laboratory Standards Wayne, PA

    Google Scholar 

  8. K Manavi H Young D Clutterbuch (2003) ArticleTitleSensitivity of microscopy for the rapid diagnosis of gonorrhoea in men and women and the role of gonorrhoea serovars Int J STD AIDS 14 390–4 Occurrence Handle12816666 Occurrence Handle10.1258/095646203765371277

    Article  PubMed  Google Scholar 

  9. K Manavi H Young A McMillan (2005) ArticleTitleThe outcome of oropharyngeal gonorrhoea treatment with different regimens Int J STD AIDS 16 68–70 Occurrence Handle15705277 Occurrence Handle1:STN:280:DC%2BD2M%2Fns1Kmuw%3D%3D Occurrence Handle10.1258/0956462052932566

    Article  PubMed  CAS  Google Scholar 

  10. MY Khan RP Gruninger SM Nelson SR Obald (1983) ArticleTitleComparative in vitro activity of cefodizime, ceftazidime, aztreonam, and other selected antimicrobial agents against Neisseria gonorrhoeae Antimicrob Agents Chemother 23 477–8 Occurrence Handle6303215 Occurrence Handle1:CAS:528:DyaL3sXhsVSnsbc%3D

    PubMed  CAS  Google Scholar 

  11. RN Jones AL Barry C Thornbery HW Wilson (1981) ArticleTitleIn vitro antimicrobial activity evaluation of cefodizime (HR221), a new semisynthetic cephalosporin Antimicrob Agents Chemother 20 760–8 Occurrence Handle6275785 Occurrence Handle1:CAS:528:DyaL38XmsFGhug%3D%3D

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, School of Medicine, University of Occupational and Environmental Health Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan

    Tetsuro Matsumoto & Tetsuro Muratani

  2. Department of Urology, Shin-Fukuoka Mizumaki Hospital, Fukuoka, Japan

    Koichi Takahashi

  3. Yoshino Clinic, Kitakyushu, Japan

    Toshihiro Ikuyama

  4. Yokoo Clinic, Saga, Japan

    Daisuke Yokoo

  5. Ando Ladies Clinic, Kitakyushu, Japan

    Yukiko Ando

  6. Sato Yumiko Ladies Clinic, Kitakyushu, Japan

    Yumiko Sato

  7. Sato Clinic, Kitakyushu, Japan

    Motoko Kurashima

  8. Angel Hospital, Kitakyushu, Japan

    Hiroshi Shimokawa & Shigeaki Yanai

Authors
  1. Tetsuro Matsumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tetsuro Muratani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Koichi Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Toshihiro Ikuyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Daisuke Yokoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yukiko Ando
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yumiko Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Motoko Kurashima
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hiroshi Shimokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Shigeaki Yanai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tetsuro Matsumoto.

About this article

Cite this article

Matsumoto, T., Muratani, T., Takahashi, K. et al. Multiple doses of cefodizime are necessary for the treatment of Neisseria gonorrhoeae pharyngeal infection. J Infect Chemother 12, 145–147 (2006). https://doi.org/10.1007/s10156-006-0444-0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10156-006-0444-0

Key words

Search

Navigation