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Prevalence of Chlamydophila pneumoniae among Bangladeshi children under age 5 years with acute respiratory infections

  • ORIGINAL ARTICLE
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Journal of Infection and Chemotherapy

Abstract

Despite major improvements in the diagnosis of pathogenic organisms causing acute respiratory infections (ARIs), details of infections caused by atypical pathogens are not well understood, particularly in developing countries. This clinical and epidemiological research was conducted in Bangladesh to explore the prevalence of atypical pathogens in causing childhood pneumonia. Sixty-four children with ARI were studied at the Pediatric Outpatient Department of Dhaka Medical College Hospital, Bangladesh, during September through December 2000. In addition to clinical examination, hematological, radiological, and bacteriological examinations were performed. Antibody titers from paired sera against Mycoplasma pneumoniae and Legionella spp. in the acute and convalescent phases revealed that none of these children were infected with M. pneumoniae, while only one serum sample was positive for L. pneumophila serogroup 4. Antibody titers against Chlamydophila (Chlamydia) pneumoniae, determined by an indirect microimmunofluorescence method, and by an enzyme-linked immunosorbent assay (ELISA) kit (HITAZYME C. pneumoniae kit) indicated that 13 children (20.3%) were infected with C. pneumoniae. Our results indicate a high prevalence rate of C. pneumoniae, suggesting it is as an important causative pathogen of childhood pneumonia in Bangladesh.

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Author information

Authors and Affiliations

  1. Department of Microbiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan

    Tetsuya Matsumoto

  2. Oguni Public Hospital, Kumamoto, Japan

    Katsumi Matsumura

  3. Department of Microbiology, Institute of Public Health, Dhaka, Bangladesh

    Kazi Selim Anwar

  4. Department of Paediatrics, Dhaka Medical College Hospital, Dhaka, Bangladesh

    Abid Hossain Mollah & Nazmun Nahar

  5. Clinical Laboratory Department, Toho University School of Medicine, Tokyo, Japan

    Hinako Murakami

  6. Mitsubishi Kagaku Bio-Clinical Laboratories, Tokyo, Japan

    Intetsu Kobayashi

  7. Hitachi Chemical Co., Ltd., Hitachi, Japan

    Kiyotaka Kawagoe

  8. Laboratory of Rikettsia and Chlamydia, First Department of Virology, National Institute of Infectious Diseases, Tokyo, Japan

    Sadashi Shiga & Toshio Kishimoto

  9. Department of Microbiology, Toho University School of Medicine, Tokyo, Japan

    Kazuhiro Tateda & Keizo Yamaguchi

Authors
  1. Tetsuya Matsumoto
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  2. Katsumi Matsumura
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  12. Keizo Yamaguchi
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Correspondence to Tetsuya Matsumoto.

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Matsumoto, T., Matsumura, K., Anwar, K. et al. Prevalence of Chlamydophila pneumoniae among Bangladeshi children under age 5 years with acute respiratory infections. J Infect Chemother 12, 139–144 (2006). https://doi.org/10.1007/s10156-006-0441-3

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  • DOI: https://doi.org/10.1007/s10156-006-0441-3

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