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Helicobacter pylori infection rate in patients with nontuberculous mycobacteriosis who are on longterm combination chemotherapy of clarithromycin and rifampicin

  • ORIGINAL ARTICLE
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Journal of Infection and Chemotherapy

Abstract

Clarithromycin resistance in Helicobacter pylori has increased the incidence of eradication failure. Clarithromycin is a key drug in the current treatment regimens for H. pylori infection, and it is also used for nontuberculous mycobacteriosis (NTM). The rate of H. pylori infection in 15 patients with NTM who were on longterm clarithromycin, rifampicin, and other drug therapy wasexamined, using the [13C] urea breath test. H. pylori was detected in 5 of the 15 patients (33.3%), whichwas significantly lower than the prevalence of H. pyloriin subjects who had routine upper gastrointestinal endoscopy in Japan (P = 0.0006). Thus, H. pylori resistance to clarithromycin is suggested to be low in patients with longterm administration, and the possibility exists of a combination of clarithromycin and rifampicin as a second-line therapy for the eradiation of H. pylori.

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References

  1. T Lind F Megraud P Unge E Bayerdorffer C O’Morain R Spiller et al. (1999) ArticleTitleThe MACH 2 study: role of omeprazole in eradication of Helicobacter pylori with 1 week triple therapies Gastroenterology 116 248–53 Occurrence Handle9922303

    PubMed  Google Scholar 

  2. HS Youn SC Baik YK Cho HO Woo YO Ahn K Kim et al. (1998) ArticleTitleComparison of Helicobacter pylori infection between Fukuoka, Japan and Chinju, Korea Helicobacter 3 9–14 Occurrence Handle10.1046/j.1523-5378.1998.08011.x Occurrence Handle9546112

    Article  PubMed  Google Scholar 

  3. InstitutionalAuthorNameEuropean Helicobacter pylori Study Group (1997) ArticleTitleCurrent European concepts in the management of Helicobacter pylori infection: the Maastricht Consensus Report Gut 41 8–13

    Google Scholar 

  4. RJ Adamek S Suerbaum B Pfaffenbach W Opferkuch (1998) ArticleTitlePrimary and acquired Helicobacter pylori resistance to clarithromycin, metronidazole and amoxicillin: influence on treatment outcome Am J Gastroenterol 93 386–9 Occurrence Handle9517645

    PubMed  Google Scholar 

  5. N Umegaki T Shimoyama D Nishiya T Suto S Fukuda A Munakata (2000) ArticleTitleClarithromycin-resistance and point mutations inthe 23S rRNA gene in Helicobacter pylori isolates from Japan J Gastroenterol Hepatol 15 906–9 Occurrence Handle10.1046/j.1440-1746.2000.02072.x Occurrence Handle11022832

    Article  PubMed  Google Scholar 

  6. A Pilotto M Franceschi M Rassu F Furlan M Scagnelli (2000) ArticleTitleIn vitro activity of rifabutin against strains of Helicobacter pylori resistant to metronidazole and clarithromycin Am J Gastroenterol 95 833–4 Occurrence Handle10.1111/j.1572-0241.2000.01900.x Occurrence Handle10710100

    Article  PubMed  Google Scholar 

  7. S Fujimura S Kato T Kawamura A Watanabe (2002) ArticleTitleIn vitro activity of rifampicin against Helicobacter pylori isolated from children and adults J Antimicrob Chemother 49 541–3 Occurrence Handle10.1093/jac/49.3.541 Occurrence Handle11864956

    Article  PubMed  Google Scholar 

  8. F Perri V Festa R Clemente M Quitadamo A Andriulli (2000) ArticleTitleRifabutin-based ‘rescue therapy’ for Helicobacter pylori infected patients after failure of standard regimens Aliment. Pharmacol. Ther. 14 311–6 Occurrence Handle10.1046/j.1365-2036.2000.00719.x Occurrence Handle10735924

    Article  PubMed  Google Scholar 

  9. S Fujimura T Kawamura N Asou H Takahashi A Watanabe (2000) ArticleTitleHelicobacter pylori infection rate in patients treated with rifampicin: eradication effect of rifampicin on Helicobacter pylori (inJapanese with English abstract) Jpn J Chemother 48 839–42

    Google Scholar 

  10. K Murakami R Sato T Okimoto K Watanabe M Nasu T Fujioka et al. (2003) ArticleTitleInfluence of anti-ulcer drugs used in Japan on the result of 13C-urea breath test for the diagnosis of Helicobacter pylori infection J.Gastroenterol 38 937–41 Occurrence Handle10.1007/s00535-003-1176-x Occurrence Handle14614600

    Article  PubMed  Google Scholar 

  11. S Ohara M Kato M Asaka T Toyota (1998) ArticleTitleStudies of 13C-urea breath test for diagnosis of Helicobacter pylori infection in Japan J.Gastroenterol 33 6–13

    Google Scholar 

  12. M Heep M Kist S Strobel D Beck N Lehn (2000) ArticleTitleSecondary resistance among 554 isolates of Helicobacter pylori after failure of therapy Eur J Clin Microbiol Infect Dis 19 538–41 Occurrence Handle10.1007/s100960000288 Occurrence Handle10968325

    Article  PubMed  Google Scholar 

  13. InstitutionalAuthorNameAmerican Thoracic Society (1997) ArticleTitleDiagnosis and treatment of disease caused by nontuberculous mycobacteria Am J Respir Crit Care Med 156 S1–S25

    Google Scholar 

  14. M Heep D Beck E Bayerdorffer N Lehn (1999) ArticleTitleRifampin and rifabutin resistance mechanism in Helicobacter pylori Antimicrob Agents Chemother 43 1497–9 Occurrence Handle10348780

    PubMed  Google Scholar 

  15. M Asaka T Kimura M Kudo H Takeda S Mitani T Miyazaki et al. (1992) ArticleTitleRelationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population Gastroenterology 102 760–6 Occurrence Handle1537513

    PubMed  Google Scholar 

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Author notes

  1. Toshinobu Yokoyama

    Present address: McMaster University, Health Sciences Centre, Room 3U24, Cardiorespiratory Research Unit, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada

Authors and Affiliations

  1. First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan

    Toshinobu Yokoyama, Takashi Kinoshita, Toru Rikimaru & Hisamichi Aizawa

Authors
  1. Toshinobu Yokoyama
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  2. Takashi Kinoshita
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  3. Toru Rikimaru
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  4. Hisamichi Aizawa
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Correspondence to Toshinobu Yokoyama.

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Yokoyama, T., Kinoshita, T., Rikimaru, T. et al. Helicobacter pylori infection rate in patients with nontuberculous mycobacteriosis who are on longterm combination chemotherapy of clarithromycin and rifampicin. J Infect Chemother 11, 173–176 (2005). https://doi.org/10.1007/s10156-005-0386-y

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  • DOI: https://doi.org/10.1007/s10156-005-0386-y

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