Abstract
Based on the pharmacokinetic-pharmacodynamic (PK-PD) parameters of ciprofloxacin in rhesus monkeys, the efficacies of levofloxacin, sparfloxacin, norfloxacin, and tosufloxacin against anthrax in humans were examined. The optimal PK-PD parameter for the prophylaxis or treatment of infection with Bacillus anthracis is not clearly defined. To evaluate the efficacy of fluoroquinolones against anthrax, PK-PD parameters and the protein-binding effect of fluoroquinolones are used. B. anthracis is very susceptible to fluoroquinolones in vitro, and levofloxacin, sparfloxacin, and tosufloxacin may be as effective against anthrax as ciprofloxacin by PK-PD analysis. However, additional studies of the in vivo model are necessary to define more clearly efficacy against anthrax and the pharmacodynamic relationship of fluoroquinolones.
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Kihira, T., Sato, J. & Shibata, T. Pharmacokinetic-pharmacodynamic analysis of fluoroquinolones against Bacillus anthracis . J Infect Chemother 10, 97–100 (2004). https://doi.org/10.1007/s10156-004-0303-9
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10156-004-0303-9