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Pharmacokinetic-pharmacodynamic analysis of fluoroquinolones against Bacillus anthracis

Abstract

Based on the pharmacokinetic-pharmacodynamic (PK-PD) parameters of ciprofloxacin in rhesus monkeys, the efficacies of levofloxacin, sparfloxacin, norfloxacin, and tosufloxacin against anthrax in humans were examined. The optimal PK-PD parameter for the prophylaxis or treatment of infection with Bacillus anthracis is not clearly defined. To evaluate the efficacy of fluoroquinolones against anthrax, PK-PD parameters and the protein-binding effect of fluoroquinolones are used. B. anthracis is very susceptible to fluoroquinolones in vitro, and levofloxacin, sparfloxacin, and tosufloxacin may be as effective against anthrax as ciprofloxacin by PK-PD analysis. However, additional studies of the in vivo model are necessary to define more clearly efficacy against anthrax and the pharmacodynamic relationship of fluoroquinolones.

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Correspondence to Tetsunari Kihira.

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Kihira, T., Sato, J. & Shibata, T. Pharmacokinetic-pharmacodynamic analysis of fluoroquinolones against Bacillus anthracis . J Infect Chemother 10, 97–100 (2004). https://doi.org/10.1007/s10156-004-0303-9

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  • DOI: https://doi.org/10.1007/s10156-004-0303-9

Key words

  • Fluoroquinolones
  • Anthrax
  • Pharmacokinetics
  • Pharmacodynamics