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Intrinsic resistance of Escherichia coli to mureidomycin A and C due to expression of the multidrug efflux system AcrAB-TolC: comparison with the efflux systems of mureidomycin-susceptible Pseudomonas aeruginosa

Abstract

 Intrinsic resistance to mureidomycin is shown in Escherichia coli. This is in contrast to Pseudomonas aeruginosa, which generally displays intrinsic resistance to a variety of antimicrobial agents, but not to mureidomycin. Isogenic efflux system mutants from both species were subjected to antibiotic susceptibility tests. These studies showed that the differences regarding the susceptibility of E. coli and P. aeruginosa to mureidomycin A and C may be explained by the expression of efflux systems that mediate resistance to mureidomycin A and C.

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Received: July 22, 2002 / Accepted: September 24, 2002

Acknowledgments We thank Masatoshi Inukai (Sankyo Co., Japan) for providing mureidomycin A and C, and we thank Keith Poole (Queen's University, Canada) and Jun-ichi Yamagishi (Dainippon Pharmaceutical Co., Japan) for providing the K and SH strains of E. coli, respectively. This research was supported by grants for scientific research to N.G. from The Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, and from the Ministry of Health, Labor, and Welfare of Japan. T.M. was the recipient of a scholarship from The Japan Scholarship Foundation.

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Gotoh, N., Murata, T., Ozaki, T. et al. Intrinsic resistance of Escherichia coli to mureidomycin A and C due to expression of the multidrug efflux system AcrAB-TolC: comparison with the efflux systems of mureidomycin-susceptible Pseudomonas aeruginosa . J Infect Chemother 9, 101–103 (2003). https://doi.org/10.1007/s10156-002-0205-2

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  • DOI: https://doi.org/10.1007/s10156-002-0205-2

  • Key words Mureidomycins
  • AcrAB-TolC
  • MexAB-OprM
  • MexCD-OprJ
  • MexXY-OprM