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A clinical, serological, and immunological study in a Japanese traveler with dengue fever

Abstract

 We describe the results of clinical, serological, and immunological studies in a Japanese traveler with dengue fever (DF). DF was confirmed by isolation of dengue virus from the serum, a positive direct reverse-transcription polymerase chain reaction (RT-PCR) test, and a high titer of anti-IgM antibody to dengue virus. Interestingly, in this patient infected by dengue virus serotype 3, we found a low CD4/CD8 ratio and a decrease in CD4 lymphocytes, a variation of cross-reaction to dengue virus serotypes 1, 2, and 4, and high serum interferon-γ levels just after a transient elevation of interleukin-12.

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Recevied: January 29, 2002 / Accepted: July 1, 2002

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Masaki, H., Hasebe, F., Ahmed, K. et al. A clinical, serological, and immunological study in a Japanese traveler with dengue fever. J Infect Chemother 8, 365–367 (2002). https://doi.org/10.1007/s10156-002-0191-9

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  • DOI: https://doi.org/10.1007/s10156-002-0191-9

  • Key words Imported tropical disease
  • IgM antibody
  • Cross-reaction
  • Interleukin (IL)-12
  • Interferon (IFN)-γ