Effective use of ustekinumab for prepouch ileitis without improvement of concomitant pouchitis
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About one half of all patients with ulcerative colitis who have had a restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) experience at least one flare of pouchitis within the first 10 years after surgery. In comparison, very little evidence is available about prepouch ileitis (PI), an acute or chronic inflammation of the afferent limb of the pouch . In a recent original article from Italy, Rottoli et al.  report a profound analysis of clinical features, endoscopic characteristics, therapeutic approaches and long-term outcomes of a large cohort of PI patients. One distinctive mark of PI is an insufficient response to single or combined immunosuppression. Although very up to date, the study covers observations from between 1989 and 2016 . Therefore, it does not allow the analysis of success rates of new biologic agents, such as vedolizumab (VDZ) or ustekinumab (UST). In this report, we will add one new piece of evidence which may expand our...
Compliance with ethical standards
Conflict of interest
Niels Teich and Andreas Stallmach received advisory and lecture fees from Janssen.
The present paper was exempt from approval.
Informed consent was obtained from the individual participant included in the study.
- 4.Bär F, Dietrich NA, Krause Tet al; German IBD Study Group (2018) Vedolizumab in the treatment of chronic, antibiotic dependent or refractory Pouchitis. Aliment Pharmacol Ther. https://doi.org/10.1111/apt.14479