Perineal wound complications are common following abdominoperineal resection. Risk factors include pre-operative radiation, indication for surgery, diabetes, obesity, and smoking. Wound management has evolved from open wound packing to primary closure with closed-suction drains. Nonetheless, complications remain high with breakdown and/or infection rates as high as 30 % or more. This can result in prolonged hospital stay, readmission, wound care needs, and significant medical costs. Adjuvant therapies have evolved, including the use of vacuum-assisted wound devices, although these result in increased healing times compared to primary closure due to the open nature of the wound with these devices. The use of closed-suction systems over a primarily closed incision has recently been developed. However, large series are lacking, in part likely due to the difficulty of application in this region. We present here the application of the Prevena Incision Management System for use in the perineal incisions due to its ease of application, low cost, and patient tolerance. This is our first abdominoperineal resection case on which we used the Prevena system, with excellent results. Ease of application was enhanced due to the premade nature of the system. Currently, we are further evaluating the efficacy of this system in decreasing wound complications, in hopes of improved outcomes in these high-risk situations, where treatment otherwise involves major reconstruction, tissue flaps, or other costly and involved procedures.