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Clinicopathological differences between right- and left-sided colonic tumors and impact upon survival

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Abstract

Aim

This study is to analyze the clinicopathological differences between right- and left-sided colonic tumors and to evaluate the impact upon the patient’s survival.

Methods

In a period of 5 years (2004–2009), 453 patients were diagnosed with colorectal cancer.

Results

From a total of 453 patients diagnosed with colon cancer, 56.5% of them were men, while 43.5% of them were women. Right-sided colonic tumors were diagnosed in 54.53% of the patients compared to the 45.47% of patients with left-sided colonic tumors. The size of colonic tumors is statistically significant greater in right-sided colonic tumors compared to left ones (P < 0.001). Left-sided colon cancer patients identified to have a statistically significant better overall 5-year survival rate compared to right-sided ones (P < 0.001).

Conclusion

Based upon our results, there is a different biological profile between right- and left-sided colonic tumors.

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References

  1. Wray CM, Ziogas A, Hinojosa MW, Le H, Stamos MJ, Zell JA (2009) Tumor subsite location within the colon is prognostic for survival after colon cancer diagnosis. Dis Colon Rectum 52(8):1359–1366

    PubMed  Google Scholar 

  2. Benedix F, Kube R, Meyer F, Schmidt U, Gastinger I, Lippert H (2010) Comparison of 17,641 patients with right- and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival. Dis Colon Rectum 53(1):57–64

    PubMed  Google Scholar 

  3. Kabat GC, Miller AB, Jain M, Rohan TE (2007) A cohort study of dietary iron and heme iron intake and risk of colorectal cancer in women. Br J Cancer 97(1):118–122

    Article  CAS  PubMed  Google Scholar 

  4. Chua AC, Klopcic B, Lawrance IC, Olynyk JK, Trinder D (2010) Iron: an emerging factor in colorectal carcinogenesis. World J Gastroenterol 16(6):663–672

    Article  CAS  PubMed  Google Scholar 

  5. Papagiorgis P, Oikonomakis I, Karapanagiotou I, Wexner SD, Nikiteas N (2006) The impact of tumor location on the histopathologic expression of colorectal cancer. J BUON 11:317–321

    CAS  PubMed  Google Scholar 

  6. Bilimoria K, Palis B, Stewart A, Bentrem DJ, Freel AC, Sigurdson ER, Talamonti MS (2008) Impact of tumor location on nodal evaluation for colon cancer. Dis Colon Rectum 51:154–161

    Article  PubMed  Google Scholar 

  7. Kanellos I, Zacharakis E, Kanellos D, Pramateftakis MG, Tsahalis T, Altsitsiadis E, Betsis D (2006) Prognostic significance of CEA levels and detection of CEA mRNA in draining venous blood in patients with colorectal cancer. J Surg Oncol 94:3–8

    Article  CAS  PubMed  Google Scholar 

  8. Kanellos I, Zacharakis E, Kanellos D, Pramateftakis MG, Betsis D (2006) Prognostic significance of CEA levels and positive cytology in peritoneal washings in patients with colorectal cancer. Colorectal Dis 8:436–440

    Article  CAS  PubMed  Google Scholar 

  9. Kanellos I, Vasiliadis K, Angelopoulos S, Tsachalis T, Pramateftakis MG, Mantzoros I, Betsis D (2004) Anastomotic leakage following anterior resection for rectal cancer. Tech Coloproctol 8:s79–s81

    Article  PubMed  Google Scholar 

  10. Demetriades H, Kanellos I, Blouhos K, Tsachalis T, Vasiliadis K, Pramateftakis MG (2004) Betsis D. Tech Coloproctol 8(Suppl 1):s72–s75

    Article  PubMed  Google Scholar 

  11. Kanellos D, Kitsios G, Kanellos I, Demetriades H, Pramateftakis MG, Angelopoulos S, Betsis D (2004) Anaemia as a symptom of right colon cancer. Tech Coloproctol 8:s62–s64

    Article  PubMed  Google Scholar 

  12. Kanellos I, Blouhos K, Demetriades H, Pramateftakis MG, Mantzoros I, Zacharakis E, Betsis D (2004) The failed intraperitoneal colon anastomosis after colon resection. Tech Coloproctol 8:s53–s55

    Article  PubMed  Google Scholar 

  13. Demetriades H, Kanellos I, Vasiliadis K, Angelopoulos S, Vergos O, Kanellos D, Betsis D (2004) Age-associated prognosis following curative resection for colorectal cancer. Tech Coloproctol 8:s144–s146

    Article  PubMed  Google Scholar 

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Conflict of interest

The authors declare that they have no conflict of interest related to the publication of this article.

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Correspondence to G. Christodoulidis.

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Christodoulidis, G., Spyridakis, M., Symeonidis, D. et al. Clinicopathological differences between right- and left-sided colonic tumors and impact upon survival. Tech Coloproctol 14 (Suppl 1), 45–47 (2010). https://doi.org/10.1007/s10151-010-0622-z

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  • DOI: https://doi.org/10.1007/s10151-010-0622-z

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