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Synchronous collision malignant melanoma and adenocarcinoma of the rectum

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Abstract

“Collision tumors” consist of two independent but coexisting tumors. This uncommon situation might be easily mistaken for a composite tumor where one histogenetic event originates from two apparently distinct neoplasms. Colorectal collisions are particularly unusual; here, we report the exceedingly rare case of a 61-year-old man with malignant melanoma and adenocarcinoma colliding in the rectum. Collision tumors have an idiopathic pathophysiology and in fact “accidental meeting” is accepted by many authors. This article discusses the concepts about cancer development, which are overlooked by this hypothesis, another theory to explain that this rare occurrence involves microenvironment changes.

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Authors and Affiliations

  1. Department of Gastroenterology, Division of Colorectal Surgery, Hospital das Clinicas, University of Sao Paulo, School of Medicine, Sao Paulo, Brazil

    A. R. Dias, R. A. Pinto, E. Mory, S. C. Nahas & I. Cecconello

  2. Department of Pathology, Hospital das Clinicas, University of Sao Paulo, School of Medicine, Sao Paulo, Brazil

    I. C. Silva & S. A. C. Siqueira

  3. Department of Colorectal Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, Fl, 33331, USA

    R. A. Pinto & S. D. Wexner

Authors
  1. A. R. Dias
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  2. R. A. Pinto
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  3. E. Mory
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  4. I. C. Silva
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  5. S. A. C. Siqueira
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  6. S. C. Nahas
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  7. I. Cecconello
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  8. S. D. Wexner
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Correspondence to R. A. Pinto.

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Dias, A.R., Pinto, R.A., Mory, E. et al. Synchronous collision malignant melanoma and adenocarcinoma of the rectum. Tech Coloproctol 14, 181–184 (2010). https://doi.org/10.1007/s10151-010-0571-6

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  • DOI: https://doi.org/10.1007/s10151-010-0571-6

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