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Prognosis of Japanese metastatic renal cell carcinoma patients in the targeted therapy era

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Abstract

Background

The aims of this study were to investigate prognosis and validate prognostic models [Memorial Sloan-Kettering Cancer Center (MSKCC), International Metastatic Renal Cell Carcinoma Data Consortium (IMDC), and Japanese metastatic renal cancer (JMRC) models] in the targeted therapy era in Japanese patients with metastatic renal cell carcinoma.

Methods

We retrospectively analyzed 692 patients who were diagnosed with mRCC from January 2008 to August 2018 in the Michinoku Japan Urological Cancer Study Group database. Nivolumab as sequential therapy was widely used. Other immune checkpoint inhibitors were excluded from this study.

Results

The median overall survival (95% confident interval) in all, MSKCC favorable, intermediate, and poor risk patients was 41.0 months (33.9–46.8), not reached (63.5 to not estimable), 46.8 months (37.1–52.9), and 10.4 months (8.9–14.4), respectively. The median overall survival (95% confident interval) in IMDC favorable, intermediate, and poor risk patients was not reached (61.6 to not estimable), 47.4 months (41.4–56.5), and 11.5 (9.9–16.3), respectively. The c-index of the MSKCC, IMDC, and JMRC models calculated at mRCC diagnosis was 0.680, 0.689, and 0.700, respectively. No statistical differences were found in the c-index among the models.

Conclusion

While the real-world overall survival in Japanese patients with mRCC in the targeted therapy era improved compared to that previously reported in the cytokine era, there was no clear difference in the survival of poor risk patients between these eras. There were no differences in the superiority among the models.

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Acknowledgements

The authors would like to thank Yoichi Arai, Koji Mitsuzuka, Takahiro Kojima, and Kento Morozumi for their invaluable support with data collection. And we would also like to thsank Enago (www.enago.jp) for the English language editing.

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Authors and Affiliations

  1. Department of Urology, Yamagata University Faculty of Medicine, Iida-Nishi 2-2-2, Yamagata, 990-9585, Japan

    Sei Naito, Tomoyuki Kato & Norihiko Tsuchiya

  2. Department of Urology, Akita University Graduate School of Medicine, 1-1-1, Hondo, Akita, 010-8543, Japan

    Kazuyuki Numakura, Shintaro Narita & Tomonori Habuchi

  3. Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 0368562, Japan

    Shingo Hatakeyama, Hayato Yamamoto & Chikara Ohyama

  4. Department of Urology, Fukushima Medical University School of Medicine, 1 hikarigaoka, Fukushima, 960-1295, Japan

    Tomoyuki Koguchi, Soichiro Ogawa & Yoshiyuki Kojima

  5. Department of Urology, University of Tsukuba Graduate School of Medicine, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan

    Shuya Kandori & Hiroyuki Nishiyama

  6. Department of Urology, Tohoku University School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan

    Yoshihide Kawasaki & Akihiro Ito

  7. Department of Urology, Miyagi Cancer Center, 47-1, Nodayama, Shiote, Medeshima, Natori, Miyagi, 981-1293, Japan

    Hisanobu Adachi & Sadafumi Kawamura

  8. Department of Urology, Iwate Medical University School of Medicine, Yahaba 2-1-1, Shiwa, Iwate, 028-3695, Japan

    Renpei Kato & Wataru Obara

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  1. Sei Naito
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Correspondence to Sei Naito.

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Naito, S., Kato, T., Numakura, K. et al. Prognosis of Japanese metastatic renal cell carcinoma patients in the targeted therapy era. Int J Clin Oncol 26, 1947–1954 (2021). https://doi.org/10.1007/s10147-021-01979-9

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  • DOI: https://doi.org/10.1007/s10147-021-01979-9

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