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Second primary cancers: a retrospective analysis of real world data using the enhanced medical research engine ConSoRe in a French comprehensive cancer center

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Abstract

Background

Second primary cancers (SPC) account for 18% of all cancers. We used the enhanced medical/health data mining tool ConSoRe to search aggregated data, analyze electronic patient records (EPR), and better characterize patients with SPC.

Methods

This retrospective cohort study used ConSoRe to identify EPRs from patients with SPC referred to the regional cancer center Leon Bérard from 1993 to 2017, and examined characteristics of patients with SPC, frequencies of first primary cancer (FPC) localization in the global population of patients with SPC, and time to SPC. Data set was extracted on January 1, 2018.

Results

Among 296,530 EPRs, we identified 157,187 patients with FPC, including 13,002 (8%) patients with SPC. Between 2000 and 2010, the rate of SPC was 34%, and 52% of SPC were identified in the last years (2010–2017). In men, main cancers were head and neck cancer, lymphoma, and prostate carcinoma accounting for 15.6%, 12.8%, and 10.5% of FPC, while the three most common SPC were head and neck cancer (13.2%), lung cancer (11.8%) and lymphoma (9.2%). In women, breast cancers, lymphoma, and skin cancers accounted for 48.8%, 8%, and 5.1% of first cancers, and for 31.1%, 7% and 6% of SPC.

Conclusion

The data mining tool ConSoRe contributes to access to real world data, and to better characterize patients with SPC. Expanding such approach to any comprehensive center will allow a global overview of the follow-up of patients with cancer, and help to improve long-term management and adapt surveillance.

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Availability of data and materials

The data that support the findings of this study are not publicly available. Data contain information that could compromise privacy of the research participants.

The Electronic Patient Records (EPR) procedure was approved by the French data protection authority (Commission Nationale de l’Informatique et des Libertés CNIL, MR004, approval number H001-DPI-300746,) with respect to any automatic processing of personal data, in accordance with the provisions of French Law of 6 January 1978 "Loi Informatique et Libertés", as amended. The study received approval from the local Ethics Committee (Comité de Protection des Personnes Lyon Sud-Est IV) in May 2019. EPR searches and extractions of data relative to each patient cancer (gender, year of birth, occurrence of primary cancers and evolution, including loco-regional relapse or metastatic progression, or death, and second primary cancers) have been declared. Patients received an information sheet and were offered the possibility to accept or refuse the participation to this non-interventional study.

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Acknowledgements

The authors thank Sophie DARNIS PhD for helpful comments and valuable help for medical editorial assistance.

Funding

No specific funding received.

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Authors and Affiliations

  1. Leon Berard Cancer Center, 28 Rue Laennec, 69008, Lyon, France

    Pierre-Etienne Heudel, Béatrice Fervers, Thierry Durand, Sylvie Chabaud, Anne-Sophie Michallet, Frédéric Gomez, Michel Rivoire, Thomas Bachelot, Line Claude, Catherine Chassagne-Clement, Franck Pilleul, Thomas Mognetti, Bruno Russias, Jean-Luc Soubirou, Gisèle Chvetzoff & David Pérol

  2. Leon Berard Cancer Center, Claude Bernard University of Lyon I, 28 Rue Laennec, 69008, Lyon, France

    Jean-Yves Blay

  3. Leon Berard Cancer Center, 28 Rue Laënnec, Cedex 08, 69373, Lyon, France

    Pierre-Etienne Heudel

Authors
  1. Pierre-Etienne Heudel
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  2. Béatrice Fervers
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  3. Thierry Durand
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  9. Line Claude
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  15. Gisèle Chvetzoff
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Contributions

P-EH, BF, TD, -ASM, FG, MR, TB, LC, CC-C, FP, TM, BR, J-LS, GC, DP, J-YB participated in data collection, P-EH and SC performed the analysis, all authors wrote, read, and approved the final manuscript.

Corresponding author

Correspondence to Pierre-Etienne Heudel.

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Heudel, PE., Fervers, B., Durand, T. et al. Second primary cancers: a retrospective analysis of real world data using the enhanced medical research engine ConSoRe in a French comprehensive cancer center. Int J Clin Oncol 26, 1793–1804 (2021). https://doi.org/10.1007/s10147-021-01963-3

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  • DOI: https://doi.org/10.1007/s10147-021-01963-3

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