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Table 4 Systematic analyses of nomogram-derived cutoffs of the externally validated nomograms

From: External validation of the Briganti 2019 nomogram to identify candidates for extended pelvic lymph node dissection among patients with high-risk clinically localized prostate cancer

Briganti 2019 [7] Number of patients, n (%) NPV
Below the cutoff (ePLND not recommended) Above the cutoff (ePLND recommended)
Cutoff Total Without hLNI§§ With hLNI Total Without hLNI With hLNI¶¶
2 8 (2.9) 8 (3.1) 0 (0) 270 (97.1) 251 (96.9) 19 (100) 100
3 30 (10.8) 30 (11.6) 0 (0) 248 (89.2) 229 (88.4) 19 (100) 100
4 48 (17.3) 48 (18.5) 0 (0) 230 (82.7) 211 (81.5) 19 (100) 100
5 56 (20.1) 56 (21.6) 0 (0) 222 (79.9) 203 (78.4) 19 (100) 100
6 69 (24.8) 68 (26.3) 1 (5.3) 209 (75.2) 191 (73.7) 18 (94.7) 98.6
7 84 (30.2) 83 (32.0) 1 (5.3) 194 (69.8) 176 (68.0) 18 (94.7) 98.8
8 100 (36.0) 98 (37.8) 2 (10.5) 178 (64.0) 161 (62.2) 17 (89.5) 98.0
9 113 (40.6) 110 (42.5) 3 (15.8) 165 (59.4) 149 (57.5) 16 (84.2) 97.3
10 120 (43.2) 117 (45.2) 3 (15.8) 158 (56.8) 142 (54.8) 16 (84.2) 97.5
15 170 (61.2) 164 (63.3) 6 (31.6) 108 (38.8) 95 (36.7) 13 (68.4) 96.5
20 195 (70.1) 187 (72.2) 8 (42.1) 83 (29.9) 72 (27.8) 11 (57.9) 95.9
25 211 (75.9) 201 (77.6) 10 (52.6) 67 (24.1) 58 (22.4) 9 (47.4) 95.3
30 226 (81.3) 213 (82.2) 13 (68.4) 52 (18.7) 46 (17.8) 6 (31.6) 94.2
40 251 (90.3) 237 (91.5) 14 (73.7) 27 (9.7) 22 (8.5) 5 (26.3) 94.4
50 266 (95.7) 250 (96.5) 16 (84.2) 12 (4.3) 9 (3.5) 3 (15.8) 94.0
60 275 (98.9) 257 (99.2) 18 (94.7) 3 (1.1) 2 (0.8) 1 (5.3) 93.5
70 275 (98.9) 257 (99.2) 18 (94.7) 3 (1.1) 2 (0.8) 1 (5.3) 93.5
80 278 (100) 259 (100) 19 (100) 0 (0) 0 (0) 0 (0) 93.2
Nomogram Number of patients, n (%) NPV
Below the cutoff 7% Above the cutoff 7%
Total Without hLNI§§ With hLNI Total Without hLNI With hLNI¶¶
Briganti 2019 [7] 84 (30.2) 83 (32.0) 1 (5.3) 194 (69.8) 176 (68.0) 18 (94.7) 98.8
Briganti 2017 [16] 40 (14.4) 39 (15.1) 1 (5.3) 238 (85.6) 220 (84.9) 18 (94.7) 97.5
Briganti 2012 [17] 33 (11.9) 33 (12.7) 0 (0) 245 (88.1) 226 (87.3) 19 (100) 100
MSKCC [18] 34 (12.2) 34 (13.1) 0 (0) 244 (87.8) 225 (86.9) 19 (100) 100
Partin 2017 [19] 121 (58.5) 118 (60.5) 3 (25.0) 86 (41.5) 77 (39.5) 9 (75.0) 97.5
Japan PC table [20] 97 (46.9) 96 (49.2) 1 (8.3) 110 (53.1) 99 (50.8) 11 (91.7) 99.0
  1. §§Percentage is indicative of specificity
  2. ¶¶Percentage is indicative of sensitivity