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Progress on treatment of MET signaling pathway in non-small cell lung cancer

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Abstract

MET activation includes gene mutation, amplification, and protein overexpression. Clinical evidence suggests that MET activation is both a primary oncogenic driver in lung cancer, and a secondary driver after acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Several small molecule TKIs have already shown to be effective in the MET pathway. However, the activation form and the diagnostic criteria of MET oncogene are still controversial, especially in patients resistant to EGFR TKIs or ALK TKIs. With the development of new MET inhibitors, a quantity of emerging trials has focused on the mechanism of acquired resistance to MET TKIs and therapeutic strategies after resistance.

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Authors and Affiliations

  1. Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, China

    Xiaoqing Yu & Yun Fan

  2. Department of Medical Oncology, Cancer Hospital, University of Chinese Academy of Sciences, Hangzhou, China

    Xiaoqing Yu, Sizhe Yu & Yun Fan

  3. Department of Medical Oncology, Zhejiang Cancer Hospital, No 1 Banshandong Road, Gongshu District, Hangzhou, Zhejiang, China

    Xiaoqing Yu, Sizhe Yu & Yun Fan

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Yu, X., Yu, S. & Fan, Y. Progress on treatment of MET signaling pathway in non-small cell lung cancer. Int J Clin Oncol 25, 1450–1458 (2020). https://doi.org/10.1007/s10147-020-01702-0

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