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Variations in clinical features and oncologic behaviors of T1 colorectal cancer according to tumor location

International Journal of Clinical Oncology volume 25, pages 1130–1136 (2020)Cite this article

Abstract

Background

Different genetic characteristics according to tumor location result in variations in survival rates and treatment responses in advanced colorectal cancer (CRC). However, the effects of tumor location during early CRC are still unclear.

Methods

Patients with T1 CRC treated between 2003 and 2019 were enrolled from a prospectively collected database. Patients were once divided into four groups, then combined into two groups (right- and left-sided CRC) according to the tumor location, and clinical features and oncologic behaviors were compared.

Results

In total, 458 patients were analyzed. Right-sided CRC had a lower incidence of polypoid type tumor than left-sided CRC (36/126 (28.6%) vs 186/332 (56.0%), p < 0.001). There were no differences in tumor size, pathological grade, pT1 substage and lymphovascular invasion between right- and left-sided CRC. Overall, lymph nodal involvement was observed in 42/458 (9.1%) patients. Right-sided CRC had a lower rate of patients with lymph nodal involvement than left-sided CRC (6/126 (4.8%) vs 36/332 (10.8%), p = 0.04).

Conclusion

The present study revealed that there were significant differences in the macroscopic type and the incidence of lymph node involvement between right- and left-sided CRC. The clinical features and oncologic behaviors of T1 CRC are possible to vary according to tumor location.

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Acknowledgements

We thank Dr. Eichi Sasaki and Dr. Yasushi Yatabe (Aichi Cancer Center Hospital, Department of Pathology and Molecular Diagnostics) for pathological diagnosis. We also thank JAM Post Inc. (WA, USA) for proofreading our draft.

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Author notes

  1. Akira Ouchi and Kazuhiro Toriyama contributed equally to this work.

Affiliations

  1. Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, 1-1, Kanokoden, Chikusa, Nagoya, Aichi, 464-8681, Japan

    Akira Ouchi, Takashi Kinoshita, Yasuhiro Shimizu & Koji Komori

  2. Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan

    Kazuhiro Toriyama

  3. Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan

    Tsutomu Tanaka, Yasumasa Niwa & Masahiro Tajika

Authors
  1. Akira Ouchi
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  2. Kazuhiro Toriyama
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  3. Takashi Kinoshita
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  4. Tsutomu Tanaka
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  5. Yasuhiro Shimizu
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  6. Yasumasa Niwa
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  7. Masahiro Tajika
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  8. Koji Komori
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Corresponding author

Correspondence to Koji Komori.

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All authors have no potential conflicts of interest, financial or otherwise.

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The present experimental protocols were approved by the institutional review committee at ACCH.

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Ouchi, A., Toriyama, K., Kinoshita, T. et al. Variations in clinical features and oncologic behaviors of T1 colorectal cancer according to tumor location. Int J Clin Oncol 25, 1130–1136 (2020). https://doi.org/10.1007/s10147-020-01642-9

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  • DOI: https://doi.org/10.1007/s10147-020-01642-9

Keywords

  • Colorectal neoplasms
  • Endoscopic mucosal resection
  • Lymphatic metastasis