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Prognostic significance of solid growth in endometrioid endometrial adenocarcinoma

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Abstract

Background

Endometrioid endometrial cancer is the most common histological subtype of endometrial adenocarcinoma. In the FIGO grading scheme, both architectural and nuclear grade are taken into consideration. However, the specific impact of solid growth alone on endometrioid endometrial adenocarcinoma outcome is not well documented. We sought to assess the degree of impact of solid growth on lymphovascular space invasion (LVSI), myometrial invasion, tumor size, FIGO stage, lymph node metastasis (LNM), relapse-free survival (RFS) and disease-specific survival (DSS).

Methods

Paraffin blocks of 269 patients treated for endometrioid endometrial cancer were retrospectively analyzed with morphometry for solid growth percentages.

Results

A statistically significant cut-off value of 1% solid growth was found for predicting LNM and advanced stage (III or IV), myometrial invasion and LVSI (p < 0.001) and a cut-off value of 8% was found for predicting adverse survival outcome (p < 0.001). The mean DSS was significantly higher in patients with < 6% solid growth compared to patients with 6–50%, 51–75% and > 75% solid growth (p < 0.001). Although, the mean RFS and DSS were lowest in patients with 51–75% solid growth, this did not reach statistical significance in comparison to 6–50% and > 75% (p > 0.05).

Conclusion

Although > 75% solid growth was most significantly associated with many of the adverse prognostic factors, this subset did not provide prognostic superiority in predicting adverse survival when compared to subsets within 6–75% solid growth. In conclusion, although no statistically significant difference in survival was found among subdivisions of architectural grades 2 and 3, solid growth, especially ≥ 8%, appeared to be an independent prognostic factor for survival in patients with early-stage endometrioid endometrial cancer.

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Author information

Authors and Affiliations

  1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Selcuk University Hospital, Selcuk University Medical School, Konya, 60615, Turkey

    Serra Akar, Tolgay Tuyan İlhan & Çetin Çelik

  2. Department of Pathology, Selcuk University Hospital, Konya, Turkey

    Zeliha Esin Çelik

  3. Department of Pathology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey

    Sıddıka Fındık

  4. Department of Obstetrics and Gynecology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey

    Fedi Ercan

Authors
  1. Serra Akar
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  2. Zeliha Esin Çelik
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  3. Sıddıka Fındık
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  4. Tolgay Tuyan İlhan
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  5. Fedi Ercan
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  6. Çetin Çelik
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Contributions

SA: data gathering, data analysis, writing of manuscript. EÇ: data gathering, data analysis. SF: data gathering, data analysis. TTİ: data gathering. FE: data gathering. ÇÇ: supervision, contributed to the writing of manuscript.

Corresponding author

Correspondence to Serra Akar.

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Conflict of interest

S. Akar declares no conflict of interest. E. Çelik declares no conflict of interest. S. Fındık declares no conflict of interest. T. T. İlhan declares no conflict of interest. F. Ercan declares no conflict of interest. Ç. Çelik declares no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors. This was a retrospective study of paraffin-blocks and was approved by the Institutional Research Ethics Committee.

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Akar, S., Çelik, Z.E., Fındık, S. et al. Prognostic significance of solid growth in endometrioid endometrial adenocarcinoma. Int J Clin Oncol 25, 195–202 (2020). https://doi.org/10.1007/s10147-019-01529-4

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  • DOI: https://doi.org/10.1007/s10147-019-01529-4

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