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Prognostic impact of underlying lung disease in pulmonary wedge resection for lung cancer

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Abstract

Background

Pulmonary wedge resection is an option for lung cancer patients with limited cardiopulmonary preservation. As the impact of underlying lung status on the prognosis of such patients remains unclear, we assessed this issue.

Methods

A total of 149 borderline surgical candidates with localized lung cancer who had undergone wedge resection were retrospectively investigated. Clinical variables related to perioperative morbidity, local control rate, and oncological outcomes based on underlying lung disease were analyzed.

Results

According to the risk analysis of postoperative complications, underlying lung disease did not influence the surgical morbidity. Postoperative recurrence occurred in 65 patients (locoregional recurrence in 36, distant metastasis in 12, and both simultaneously in 17). Multivariate analysis revealed that emphysema on computed tomography (CT) [hazard ratio (HR) 0.45; 95% confidence interval (CI) 0.21–0.99] was an independent indicator of locoregional recurrence. Forty-four patients died of lung cancer and 29 of other causes. Multivariate analysis demonstrated that interstitial lung disease on CT (HR 1.98; 95% CI 1.01–3.89) was a predictor of poor prognosis.

Conclusion

Pulmonary wedge resection can be safely undergone by lung cancer patients regardless of pulmonary comorbidity, although underlying lung disease may influence the prognosis after wedge resection.

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Acknowledgements

We thank Hugh McGonigle, from Edanz Group (http://www.edanzediting.com/ac), for editing a draft of the manuscript.

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Authors and Affiliations

  1. Department of Thoracic and Cardiovascular Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan

    Takeshi Kawaguchi, Noriyoshi Sawabata, Norikazu Kawai, Motoaki Yasukawa, Takashi Tojo & Shigeki Taniguchi

  2. Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan

    Sachiko Miura

Authors
  1. Takeshi Kawaguchi
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  2. Noriyoshi Sawabata
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  3. Sachiko Miura
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  4. Norikazu Kawai
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  5. Motoaki Yasukawa
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  6. Takashi Tojo
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  7. Shigeki Taniguchi
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Correspondence to Takeshi Kawaguchi.

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Kawaguchi, T., Sawabata, N., Miura, S. et al. Prognostic impact of underlying lung disease in pulmonary wedge resection for lung cancer. Int J Clin Oncol 24, 366–374 (2019). https://doi.org/10.1007/s10147-018-1367-3

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  • DOI: https://doi.org/10.1007/s10147-018-1367-3

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