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Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer

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Abstract

Background

To evaluate the prognostic outcome and surgical complications in patients with early-stage cervical cancer who underwent sentinel node navigation surgery (SNNS) for hysterectomy or trachelectomy.

Methods

A total of 139 patients who underwent SNNS using 99mTc phytate between 2009 and 2015 were evaluated. No further lymph node dissection was performed when intraoperative analysis of the sentinel lymph nodes (SLNs) was negative for metastasis. We compared the surgical complications between the SNNS group and 67 matched patients who underwent pelvic lymph node dissection (PLND) after SLN mapping between 2003 and 2008. We also examined the clinical outcomes in the SNNS group.

Results

The mean number of detected SLNs was 2.5 per patient. Fourteen of the 139 patients in the SNNS group underwent PLND based on the intraoperative SLN results. The amount of blood loss, the operative time, and the number of perioperative complications were significantly less in the SNNS group than in the matched PLND group. There was no recurrence during a follow-up period ranging from 2 to 88 months (median 40 months) in the SNNS group.

Conclusions

Using SNNS for early-stage cervical cancer is safe and effective and does not increase the recurrence rate. A future multicenter trial is warranted.

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Acknowledgements

This study was supported in part by a grant-in-aid for scientific research (C) from the Japan Society for the Promotion of Science (number 17K11281).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Hideaki Yahata, Kenzo Sonoda, Keisuke Kodama, Hiroshi Yagi, Masafumi Yasunaga, Tatsuhiro Ohgami, Ichiro Onoyama, Eisuke Kaneki, Kaoru Okugawa & Kiyoko Kato

  2. Department of Obstetrics and Gynecology, Kagoshima University Hospital, Kagoshima, Japan

    Hiroaki Kobayashi

  3. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Shingo Baba & Takuro Isoda

  4. Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Yoshihiro Ohishi & Yoshinao Oda

Authors
  1. Hideaki Yahata
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  2. Hiroaki Kobayashi
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  3. Kenzo Sonoda
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  4. Keisuke Kodama
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  5. Hiroshi Yagi
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  6. Masafumi Yasunaga
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  7. Tatsuhiro Ohgami
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  8. Ichiro Onoyama
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  9. Eisuke Kaneki
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  10. Kaoru Okugawa
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  11. Shingo Baba
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  12. Takuro Isoda
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  13. Yoshihiro Ohishi
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  14. Yoshinao Oda
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  15. Kiyoko Kato
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Corresponding author

Correspondence to Hideaki Yahata.

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The authors have declared no conflicts of interest.

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Yahata, H., Kobayashi, H., Sonoda, K. et al. Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer. Int J Clin Oncol 23, 1167–1172 (2018). https://doi.org/10.1007/s10147-018-1327-y

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  • DOI: https://doi.org/10.1007/s10147-018-1327-y

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